Somatostatinski receptor 2

Somatostatinski receptor 2
Identifikatori
Simboli	SSTR2;
Vanjski ID	OMIM: 182452 MGI: 98328 HomoloGene: 37427 IUPHAR: sst2 GeneCards: SSTR2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost somatostatinskog receptora • proteinsko vezivanje • vezivanje za PDZ domen
Celularna komponenta	• integralno sa ćelijskom membranom • membrana • integralno sa ćelijskom membranom
Biološki proces	• prenos signala • G-proteinska signalizacija, spregnuta sa ciklično nukleotidnim sekundarnim glasnikom • G-proteinska signalizacija, inhibicioni put adenilat ciklaze • neuropeptidni signalni put • interćelijska signalizacija • respons na hranu • varenje • negativna regulacija ćelijske proliferacije
Pregled RNK izražavanja
	podaci
Ortolozi

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Somatostatinski receptor tip 2 je protein koji je kod čoveka kodiran SSTR2 genom..^[1]

Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR2 u znatnoj meri izražen u velikom mozgu i bubrezima.^[2]

Interakcije

Za somatostatinski receptor 2 je pokazano interaguje sa SHANK2.^[3]

Vidi isto

Somatostatinski receptor

Reference

↑ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms”. Genomics 15 (2): 449–52. DOI:10.1006/geno.1993.1088. PMID 8449518.
↑ „Entrez Gene: SSTR2 somatostatin receptor 2”.
↑ Zitzer, H; Hönck H H, Bächner D, Richter D, Kreienkamp H J (Nov 1999). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain”. J. Biol. Chem. (UNITED STATES) 274 (46): 32997–3001. DOI:10.1074/jbc.274.46.32997. ISSN 0021-9258. PMID 10551867.

Literatura

Yamada Y, Post SR, Wang K, et al. (1992). „Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. DOI:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
Reubi JC, Waser B, Schaer JC, Markwalder R (1995). „Somatostatin receptors in human prostate and prostate cancer.”. J. Clin. Endocrinol. Metab. 80 (9): 2806–14. DOI:10.1210/jc.80.9.2806. PMID 7673428.
Kagimoto S, Yamada Y, Kubota A, et al. (1994). „Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.”. Biochem. Biophys. Res. Commun. 202 (2): 1188–95. DOI:10.1006/bbrc.1994.2054. PMID 7914078.
Fujita T, Yamaji Y, Sato M, et al. (1994). „Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.”. Life Sci. 55 (23): 1797–806. DOI:10.1016/0024-3205(94)90090-6. PMID 7968260.
Patel YC, Greenwood M, Kent G, et al. (1993). „Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.”. Biochem. Biophys. Res. Commun. 192 (1): 288–94. DOI:10.1006/bbrc.1993.1412. PMID 8386508.
Fukusumi S, Kitada C, Takekawa S, et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun. 232 (1): 157–63. DOI:10.1006/bbrc.1997.6252. PMID 9125122.
Jaïs P, Terris B, Ruszniewski P, et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest. 27 (8): 639–44. DOI:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.
Lopez F, Estève JP, Buscail L, et al. (1997). „The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling.”. J. Biol. Chem. 272 (39): 24448–54. DOI:10.1074/jbc.272.39.24448. PMID 9305905.
Tsutsumi A, Takano H, Ichikawa K, et al. (1997). „Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells.”. Cell. Immunol. 181 (1): 44–9. DOI:10.1006/cimm.1997.1193. PMID 9344495.
Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol. 13 (1): 82–90. DOI:10.1210/me.13.1.82. PMID 9892014.
Kumar U, Sasi R, Suresh S, et al. (1999). „Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.”. Diabetes 48 (1): 77–85. DOI:10.2337/diabetes.48.1.77. PMID 9892225.
Zitzer H, Richter D, Kreienkamp HJ (1999). „Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.”. J. Biol. Chem. 274 (26): 18153–6. DOI:10.1074/jbc.274.26.18153. PMID 10373412.
Zitzer H, Hönck HH, Bächner D, et al. (2000). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.”. J. Biol. Chem. 274 (46): 32997–3001. DOI:10.1074/jbc.274.46.32997. PMID 10551867.
Petersenn S, Rasch AC, Presch S, et al. (2000). „Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.”. Mol. Cell. Endocrinol. 157 (1-2): 75–85. DOI:10.1016/S0303-7207(99)00161-6. PMID 10619399.
Kreienkamp HJ, Zitzer H, Richter D (2001). „Identification of proteins interacting with the rat somatostatin receptor subtype 2.”. J. Physiol. Paris 94 (3-4): 193–8. DOI:10.1016/S0928-4257(00)00204-7. PMID 11087996.
Ho MK, Yung LY, Chan JS, et al. (2001). „Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C.”. Br. J. Pharmacol. 132 (7): 1431–40. DOI:10.1038/sj.bjp.0703933. PMC 1572686. PMID 11264236.
Zatelli MC, Tagliati F, Taylor JE, et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab. 86 (5): 2161–9. DOI:10.1210/jc.86.5.2161. PMID 11344221.
Talme T, Ivanoff J, Hägglund M, et al. (2001). „Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.”. Clin. Exp. Immunol. 125 (1): 71–9. DOI:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428.
Klisovic DD, O'Dorisio MS, Katz SE, et al. (2001). „Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.”. Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930.

Vanjske veze

„Somatostatin Receptors: sst₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
MeSH somatostatin+receptor+2

[pmid8449518-1] Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms”. Genomics 15 (2): 449–52. DOI:10.1006/geno.1993.1088. PMID 8449518.

[entrez-2] „Entrez Gene: SSTR2 somatostatin receptor 2”.

[pmid10551867-3] Zitzer, H; Hönck H H, Bächner D, Richter D, Kreienkamp H J (Nov 1999). „Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain”. J. Biol. Chem. (UNITED STATES) 274 (46): 32997–3001. DOI:10.1074/jbc.274.46.32997. ISSN 0021-9258. PMID 10551867.

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