AGTR2

Angiotenzinski II receptor tip 2‎‎
Identifikatori
Simboli	AGTR2; AT2; ATGR2; MRX88
Vanjski ID	OMIM: 300034 MGI: 87966 HomoloGene: 20172 IUPHAR: AT2 GeneCards: AGTR2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • aktivnost inhibitora proteinske kinaze • receptorska aktivnost • aktivnost angiotenzin tip II receptora • aktivnost bradikininskog receptora
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• angiotenzinom posredovana vazodilatacija tokom regulacije krvnog pritiska • moždani renin-angiotenzin sistem • apoptoza • signalni put G-protein spregnutog receptora • ponašanje • regulacija krvnog pritiska
Pregled RNK izražavanja
	podaci
Ortolozi

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Angiotenzinski II receptor tip 2, (AT₂ receptor) je protein koji je kod ljudi kodiran AGTR2 genom.^[1]

Funkcija

Angiotenzin II je potentan vazokonstrikcioni hormon i primarni regulator aldosteronske sekrecije. On je važan efektor kontrole krvnog pritiska i zapremine kardiovaskularnog sistema. On deluje kroz najmanje dva tipa receptora: AT₁ i AT₂. AGTR2 pripada familiji 1 G protein-spregnutih receptora. On je integralni membranski protein. On učestvuje u funkcijama centralnog nervnog i kardiovaskularnog sistema koje su posredovane renin-angiotenzinskim sistemom. Ovaj receptor posreduje programiranu ćelijsku smrt (apoptozu). Kod odraslih osoba, on je visoko izražen u miometrijumu sa niskim nivoima u nadbubrežnoj žlezdi i jajovodima. On je visoko izražen u fetalnim bubrezima i interstinalnom sistemu. Humani AGTR2 gen se sastoji od sastoji od tri eksona na rasponu od najmanje 5 kb.^[1]

Stimulacija AT₂ receptora selektivnim agonistom CGP 42112A povećava proizvodnju azot-monoksida sluzokože.^[2]

Interakcije

Za angiotenzinski II receptor tip 2 je pokazano da interaguje sa MTUS1.^[3]

Povezano

Angiotenzinski II receptor

Reference

↑ ^1,0 ^1,1 „Entrez Gene: AGTR2 angiotensin II receptor, type 2”.
↑ Ewert S, Laesser M, Johansson B, Holm M, Aneman A, Fandriks L (March 2003). „The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa”. BMC Pharmacol. 3: 2. DOI:10.1186/1471-2210-3-2. PMC 153509. PMID 12689346.
↑ Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). „Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP”. J. Biol. Chem. 279 (28): 28989–97. DOI:10.1074/jbc.M403880200. PMID 15123706.

Literatura

de Gasparo M, Catt KJ, Inagami T, "et al." (2000). „International union of pharmacology. XXIII. The angiotensin II receptors”. Parmacol Rev. 52 (3): 415–472. PMID 10977869.
D'Amore A, Black MJ, Thomas WG (2005). „The angiotensin II type 2 receptor causes constituative growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy”. Hypertension 46 (6): 1347–1354. DOI:10.1161/01.HYP.0000193504.51489.cf. PMID 16286564.
Regitz-Zagrosek V, Neuss M, Warnecke C, et al. (1997). „Subtype 2 and atypical angiotensin receptors in the human heart.”. Basic Res. Cardiol. 91 Suppl 2: 73–7. PMID 8957548.
Berry C, Touyz R, Dominiczak AF, et al. (2002). „Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.”. Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400.
Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). „Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.”. Biochem. Biophys. Res. Commun. 183 (2): 910–6. DOI:10.1016/0006-291X(92)90570-B. PMID 1550596.
Hein L, Barsh GS, Pratt RE, et al. (1995). „Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.”. Nature 377 (6551): 744–7. DOI:10.1038/377744a0. PMID 7477266.
Ichiki T, Labosky PA, Shiota C, et al. (1995). „Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.”. Nature 377 (6551): 748–50. DOI:10.1038/377748a0. PMID 7477267.
Lazard D, Briend-Sutren MM, Villageois P, et al. (1995). „Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.”. Recept. Channels 2 (4): 271–80. PMID 7719706.
Martin MM, Elton TS (1995). „The sequence and genomic organization of the human type 2 angiotensin II receptor.”. Biochem. Biophys. Res. Commun. 209 (2): 554–62. DOI:10.1006/bbrc.1995.1537. PMID 7733925.
Chassagne C, Beatty BG, Meloche S (1995). „Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization.”. Genomics 25 (2): 601–3. DOI:10.1016/0888-7543(95)80072-T. PMID 7790004.
Koike G, Horiuchi M, Yamada T, et al. (1994). „Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.”. Biochem. Biophys. Res. Commun. 203 (3): 1842–50. DOI:10.1006/bbrc.1994.2402. PMID 7945336.
Martin MM, Su B, Elton TS (1995). „Molecular cloning of the human angiotensin II type 2 receptor cDNA.”. Biochem. Biophys. Res. Commun. 205 (1): 645–51. DOI:10.1006/bbrc.1994.2714. PMID 7999093.
Tsuzuki S, Ichiki T, Nakakubo H, et al. (1994). „Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.”. Biochem. Biophys. Res. Commun. 200 (3): 1449–54. DOI:10.1006/bbrc.1994.1613. PMID 8185599.
Servant G, Boulay G, Bossé R, et al. (1993). „Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium.”. Mol. Pharmacol. 43 (5): 677–83. PMID 8502225.
Yamada T, Horiuchi M, Dzau VJ (1996). „Angiotensin II type 2 receptor mediates programmed cell death.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 156–60. DOI:10.1073/pnas.93.1.156. PMC 40197. PMID 8552595.
Zhang J, Pratt RE (1996). „The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus.”. J. Biol. Chem. 271 (25): 15026–33. DOI:10.1074/jbc.271.25.15026. PMID 8663053.
Katsuya T, Horiuchi M, Minami S, et al. (1997). „Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome.”. Mol. Cell. Endocrinol. 127 (2): 221–8. DOI:10.1016/S0303-7207(97)04011-2. PMID 9099917.
Akishita M, Ito M, Lehtonen JY, et al. (1999). „Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth.”. J. Clin. Invest. 103 (1): 63–71. DOI:10.1172/JCI5182. PMC 407869. PMID 9884335.
Lehtonen JY, Daviet L, Nahmias C, et al. (1999). „Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.”. Mol. Endocrinol. 13 (7): 1051–60. DOI:10.1210/me.13.7.1051. PMID 10406457.
Knowle D, Ahmed S, Pulakat L (2000). „Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family.”. Regul. Pept. 87 (1-3): 73–82. DOI:10.1016/S0167-0115(99)00111-1. PMID 10710290.
Hansen JL, Servant G, Baranski TJ, et al. (2000). „Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation.”. Circ. Res. 87 (9): 753–9. PMID 11055978.

Vanjske veze

„Angiotensin Receptors: AT₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-06-16.

[entrez-1] 1,0 ^1,1 „Entrez Gene: AGTR2 angiotensin II receptor, type 2”.

[pmid12689346-2] Ewert S, Laesser M, Johansson B, Holm M, Aneman A, Fandriks L (March 2003). „The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa”. BMC Pharmacol. 3: 2. DOI:10.1186/1471-2210-3-2. PMC 153509. PMID 12689346.

[pmid15123706-3] Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). „Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP”. J. Biol. Chem. 279 (28): 28989–97. DOI:10.1074/jbc.M403880200. PMID 15123706.

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