F2RL2

Proteazom-aktivirani receptor 3
Identifikatori
Simboli	F2RL2; PAR3
Vanjski ID	OMIM: 601919 MGI: 1298208 HomoloGene: 36151 IUPHAR: PAR3 GeneCards: F2RL2 Gene
Ontologija gena
Molekularna funkcija	• odopsinu-slična receptorska aktivnost • aktivnost fosfoinozitid fosfolipaze C • receptorska aktivnost • aktivnost trombinskog receptora
Celularna komponenta	• membrana plazme • integralno sa membranom plazme
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora • koagulacija krvi • respons na ranjavanje
Pregled RNK izražavanja
	podaci
Ortolozi

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Proteazom-aktivirani receptor 3 (PAR3), ili Receptoru koagulacionog faktora II (trombina) sličan 2, je protein kodiran F2RL2 genom kod ljudi.

F2RL2 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR3 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor. F2RL2 je kofaktor za F2RL3 aktivaciju trombinom. On posreduje trombinom-podstaknutu fosfoinozitid hidrolizu. F2RL2 je izražen u nizu tkiva.^[1]

Povezano

Proteazom-aktivirani receptor

Reference

↑ „Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2”.

Literatura

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Ishihara H, Connolly AJ, Zeng D, et al. (1997). „Protease-activated receptor 3 is a second thrombin receptor in humans.”. Nature 386 (6624): 502–6. DOI:10.1038/386502a0. PMID 9087410.
Schmidt VA, Nierman WC, Maglott DR, et al. (1998). „The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets.”. J. Biol. Chem. 273 (24): 15061–8. DOI:10.1074/jbc.273.24.15061. PMID 9614115.
Xu WF, Andersen H, Whitmore TE, et al. (1998). „Cloning and characterization of human protease-activated receptor 4.”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. DOI:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465.
Guyonnet Dupérat V, Jacquelin B, Boisseau P, et al. (1998). „Protease-activated receptor genes are clustered on 5q13.”. Blood 92 (1): 25–31. PMID 9639495.
Kahn ML, Zheng YW, Huang W, et al. (1998). „A dual thrombin receptor system for platelet activation.”. Nature 394 (6694): 690–4. DOI:10.1038/29325. PMID 9716134.
Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). „Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.”. J. Biol. Chem. 273 (36): 23290–6. DOI:10.1074/jbc.273.36.23290. PMID 9722561.
Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). „Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.”. J. Clin. Invest. 103 (6): 879–87. DOI:10.1172/JCI6042. PMC 408153. PMID 10079109.
Hauck RW, Schulz C, Schömig A, et al. (1999). „alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors.”. Am. J. Physiol. 277 (1 Pt 1): L22–9. PMID 10409227.
Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). „PAR3 is a cofactor for PAR4 activation by thrombin.”. Nature 404 (6778): 609–13. DOI:10.1038/35007085. PMID 10766244.
O'Brien PJ, Prevost N, Molino M, et al. (2000). „Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.”. J. Biol. Chem. 275 (18): 13502–9. DOI:10.1074/jbc.275.18.13502. PMID 10788464.
Cumashi A, Ansuini H, Celli N, et al. (2001). „Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets.”. Thromb. Haemost. 85 (3): 533–8. PMID 11307827.
Sambrano GR, Weiss EJ, Zheng YW, et al. (2001). „Role of thrombin signalling in platelets in haemostasis and thrombosis.”. Nature 413 (6851): 74–8. DOI:10.1038/35092573. PMID 11544528.
Miike S, McWilliam AS, Kita H (2002). „Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.”. J. Immunol. 167 (11): 6615–22. PMID 11714832.
Uehara A, Sugawara S, Muramoto K, Takada H (2002). „Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2.”. J. Immunol. 169 (8): 4594–603. PMID 12370398.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Even-Ram SC, Grisaru-Granovsky S, Pruss D, et al. (2003). „The pattern of expression of protease-activated receptors (PARs) during early trophoblast development.”. J. Pathol. 200 (1): 47–52. DOI:10.1002/path.1338. PMID 12692840.
Owen WG (2003). „PAR-3 is a low-affinity substrate, high affinity effector of thrombin.”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. DOI:10.1016/S0006-291X(03)00732-0. PMID 12732212.
Tanaka N, Morita T, Nezu A, et al. (2003). „Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1).”. Life Sci. 73 (3): 301–10. DOI:10.1016/S0024-3205(03)00269-8. PMID 12757837.
„Protease-Activated Receptors: PAR3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-04.

[1] „Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2”.

[1]

F2RL2

Povezano

Reference

Literatura

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