Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom). Ovi domeni su nekovalentno vezani na ćelijskoj membrani. Dok je nekoliko transkriptnih varijanti poznato, do sada je samo jedna biološki okarakterisana.[2]
Reference
↑White GR, Varley JM, Heighway J (Jul 2000). „Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines”. Biochim Biophys Acta1491 (1-3): 75–92. PMID10760572.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res.6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID8889548.
Nagase T, Ishikawa K, Suyama M, et al. (1999). „Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”. DNA Res.5 (5): 277–86. DOI:10.1093/dnares/5.5.277. PMID9872452.
White GR, Varley JM, Heighway J (1999). „Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer.”. Oncogene17 (26): 3513–9. DOI:10.1038/sj.onc.1202487. PMID10030676.
Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). „The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.”. J. Biol. Chem.275 (42): 32387–90. DOI:10.1074/jbc.C000490200. PMID10964907.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.”. Genomics84 (1): 23–33. DOI:10.1016/j.ygeno.2003.12.004. PMID15203201.
Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature441 (7091): 315–21. DOI:10.1038/nature04727. PMID16710414.