Prostaglandinski E2 receptor edit Prostaglandinski E receptor 2 Identifikatori Simboli PTGER2; EP2 Vanjski ID OMIM: 176804 MGI: 97794 HomoloGene: 739 IUPHAR: EP2 GeneCards: PTGER2 Gene Ontologija gena Molekularna funkcija • aktivnost prostaglandinskog E receptora Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • signalni put G-protein spregnutog receptora • signalni put adenilat ciklazom aktiviranog G-protein spregnutog receptora • respons na lipopolisaharid Pregled RNK izražavanja podaci Ortolozi Vrsta Čovek Miš Entrez 5732 19217 Ensembl ENSG00000125384 ENSMUSG00000037759 UniProt P43116 Q62053 RefSeq (mRNA) NM_000956.3 NM_008964.4 RefSeq (protein) NP_000947.2 NP_032990.1 Lokacija (UCSC) Chr 14: 52.78 - 52.8 Mb Chr 14: 45.61 - 45.62 Mb PubMed pretraga [1] [2] Prostaglandinski E2 receptor (EP2) je prostaglandinski receptor za prostaglandin E2. On je kodiran ljudskim genom PTGER2.[1] On je povezan sa aspirinom indukovanom astmom.[2] Mehanizam Ovaj protein je G protein spregnuti receptor, koji aktivira G protein Gs.[3] Reference ↑ „Entrez Gene: PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa”.  ↑ Jinnai N, Sakagami T, Sekigawa T, et al. (December 2004). „Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach”. Hum. Mol. Genet. 13 (24): 3203–17. DOI:10.1093/hmg/ddh332. PMID 15496426.  ↑ Invitrogen Online Ordering: Prostanoid Receptor PTGER2 Assays[mrtav link] Literatura Duncan AM, Anderson LL, Funk CD, et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114.  Regan JW, Bailey TJ, Pepperl DJ, et al. (1994). „Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.”. Mol. Pharmacol. 46 (2): 213–20. PMID 8078484.  Bastien L, Sawyer N, Grygorczyk R, et al. (1994). „Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.”. J. Biol. Chem. 269 (16): 11873–7. PMID 8163486.  An S, Yang J, Xia M, Goetzl EJ (1994). „Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2.”. Biochem. Biophys. Res. Commun. 197 (1): 263–70. DOI:10.1006/bbrc.1993.2470. PMID 8250933.  Stillman BA, Breyer MD, Breyer RM (1999). „Importance of the extracellular domain for prostaglandin EP(2) receptor function.”. Mol. Pharmacol. 56 (3): 545–51. PMID 10462542.  Smock SL, Pan LC, Castleberry TA, et al. (1999). „Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype.”. Gene 237 (2): 393–402. DOI:10.1016/S0378-1119(99)00323-6. PMID 10521663.  Desai S, April H, Nwaneshiudu C, Ashby B (2001). „Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.”. Mol. Pharmacol. 58 (6): 1279–86. PMID 11093764.  Duckworth N, Marshall K, Clayton JK (2002). „An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women.”. J. Endocrinol. 172 (2): 263–9. DOI:10.1677/joe.0.1720263. PMID 11834444.  Kyveris A, Maruscak E, Senchyna M (2002). „Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.”. Mol. Vis. 8: 51–8. PMID 11951086.  Takafuji VA, Evans A, Lynch KR, Roche JK (2003). „PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer.”. Prostaglandins Leukot. Essent. Fatty Acids 66 (1): 71–81. DOI:10.1054/plef.2001.0299. PMID 12051958.  Scandella E, Men Y, Gillessen S, et al. (2002). „Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.”. Blood 100 (4): 1354–61. DOI:10.1182/blood-2001-11-0017. PMID 12149218.  Okuyama T, Ishihara S, Sato H, et al. (2002). „Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines.”. J. Lab. Clin. Med. 140 (2): 92–102. PMID 12228765.  Konger RL, Scott GA, Landt Y, et al. (2003). „Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.”. Am. J. Pathol. 161 (6): 2065–78. DOI:10.1016/S0002-9440(10)64485-9. PMC 1850902. PMID 12466123.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Abulencia JP, Gaspard R, Healy ZR, et al. (2003). „Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells”. J. Biol. Chem. 278 (31): 28388–94. DOI:10.1074/jbc.M301378200. PMID 12743126.  Richards JA, Brueggemeier RW (2003). „Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes”. J. Clin. Endocrinol. Metab. 88 (6): 2810–6. DOI:10.1210/jc.2002-021475. PMID 12788892.  Sun HS, Hsiao KY, Hsu CC, et al. (2003). „Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor”. Endocrinology 144 (9): 3934–42. DOI:10.1210/en.2003-0289. PMID 12933667.  Bradbury DA, Newton R, Zhu YM, et al. (2004). „Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors”. J. Biol. Chem. 278 (50): 49954–64. DOI:10.1074/jbc.M307964200. PMID 14517215.  Moreland RB, Kim N, Nehra A, et al. (2004). „Functional prostaglandin E (EP) receptors in human penile corpus cavernosum”. Int. J. Impot. Res. 15 (5): 362–8. DOI:10.1038/sj.ijir.3901042. PMID 14562138.  Sugimoto Y, Nakato T, Kita A, et al. (2004). „A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors”. J. Biol. Chem. 279 (12): 11016–26. DOI:10.1074/jbc.M307404200. PMID 14699136.  Povezano Eikozanoidni receptor Vanjske veze „Prostanoid Receptor: EP2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

Index: pl ar de en es fr it arz nl ja pt ceb sv uk vi war zh ru af ast az bg zh-min-nan bn be ca cs cy da et el eo eu fa gl ko hi hr id he ka la lv lt hu mk ms min no nn ce uz kk ro simple sk sl sr sh fi ta tt th tg azb tr ur zh-yue hy my ace als am an hyw ban bjn map-bms ba be-tarask bcl bpy bar bs br cv nv eml hif fo fy ga gd gu hak ha hsb io ig ilo ia ie os is jv kn ht ku ckb ky mrj lb lij li lmo mai mg ml zh-classical mr xmf mzn cdo mn nap new ne frr oc mhr or as pa pnb ps pms nds crh qu sa sah sco sq scn si sd szl su sw tl shn te bug vec vo wa wuu yi yo diq bat-smg zu lad kbd ang smn ab roa-rup frp arc gn av ay bh bi bo bxr cbk-zam co za dag ary se pdc dv dsb myv ext fur gv gag inh ki glk gan guw xal haw rw kbp pam csb kw km kv koi kg gom ks gcr lo lbe ltg lez nia ln jbo lg mt mi tw mwl mdf mnw nqo fj nah na nds-nl nrm nov om pi pag pap pfl pcd krc kaa ksh rm rue sm sat sc trv stq nso sn cu so srn kab roa-tara tet tpi to chr tum tk tyv udm ug vep fiu-vro vls wo xh zea ty ak bm ch ny ee ff got iu ik kl mad cr pih ami pwn pnt dz rmy rn sg st tn ss ti din chy ts kcg ve

Prefix: a b c d e f g h i j k l m n o p q r s t u v w x y z 0 1 2 3 4 5 6 7 8 9

Portal di Ensiklopedia Dunia

Agama

Bahasa

Biografi

Budaya

Ekonomi

Elektronika

Film

Filsafat

Geografi

Indonesia

Ilmu

Lingkungan

Masyarakat

Matematika

Militer

Mitologi

Musik

Olahraga

Pendidikan

Politik

Sastra

Sejarah

Seni

Teknologi