GPRC6A

G protein spregnuti receptor, familija C, grupa 6, član A
Identifikatori
Simboli	GPRC6A; GPCR; bA86F4.3
Vanjski ID	OMIM: 613572 MGI: 2429498 HomoloGene: 17529 IUPHAR: GPRC6 GeneCards: GPRC6A Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora
Celularna komponenta	• ćelijska membrana • ćelijska površina • integralno sa membranom
Biološki proces	• kalcijum posredovan signalizacija • respons na aminokiselinski stimulus
Ortolozi

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G protein spregnuti receptor familija C group 6 član A je protein koji je kod ljudi kodiran GPRC6A genom.^[1] Ovaj receptor funkcioniše kao senzor L-aminokiselina,^[2] osteokalcina,^[3] i steroida.^[4]

Klinički značaj

GPRC6A je takođe povezan sa progresijom raka prostate, i pokazano je da posreduje brz, negenomiski respons ćelija kancera prostate na testosteron.^[5]

Reference

↑ „Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A”.
↑ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589–97. DOI:10.1124/mol.104.007559. PMID 15576628.
↑ Pi M, Wu Y, Quarles LD (July 2011). „GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo”. J. Bone Miner. Res. 26 (7): 1680–3. DOI:10.1002/jbmr.390. PMID 21425331.
↑ Pi M, Parrill AL, Quarles LD (December 2010). „GPRC6A mediates the non-genomic effects of steroids”. J. Biol. Chem. 285 (51): 39953–64. DOI:10.1074/jbc.M110.158063. PMID 20947496.
↑ Pi M, Quarles LD (June 2011). „GPRC6A regulates prostate cancer progression”. Prostate 72 (4): 399–409. DOI:10.1002/pros.21442. PMID 21681779.

Literatura

Harrington JJ, Sherf B, Rundlett S, et al. (2001). „Creation of genome-wide protein expression libraries using random activation of gene expression.”. Nat. Biotechnol. 19 (5): 440–5. DOI:10.1038/88107. PMID 11329013.
Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1–3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
Wellendorph P, Bräuner-Osborne H (2004). „Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor”. Gene 335: 37–46. DOI:10.1016/j.gene.2004.03.003. PMID 15194188.
Wellendorph P, Hansen KB, Balsgaard A, et al. (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589–97. DOI:10.1124/mol.104.007559. PMID 15576628.
Pi M, Faber P, Ekema G, et al. (2006). „Identification of a novel extracellular cation-sensing G-protein-coupled receptor”. J. Biol. Chem. 280 (48): 40201–9. DOI:10.1074/jbc.M505186200. PMC 1435382. PMID 16199532.

Vanjske veze

MeSH GPRC6A+protein,+human
„Calcium-Sensing Receptors: GPRC₆”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[entrez-1] „Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A”.

[pmid15576628-2] Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). „Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids”. Mol. Pharmacol. 67 (3): 589–97. DOI:10.1124/mol.104.007559. PMID 15576628.

[pmid21425331-3] Pi M, Wu Y, Quarles LD (July 2011). „GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo”. J. Bone Miner. Res. 26 (7): 1680–3. DOI:10.1002/jbmr.390. PMID 21425331.

[pmid20947496-4] Pi M, Parrill AL, Quarles LD (December 2010). „GPRC6A mediates the non-genomic effects of steroids”. J. Biol. Chem. 285 (51): 39953–64. DOI:10.1074/jbc.M110.158063. PMID 20947496.

[pmid21681779-5] Pi M, Quarles LD (June 2011). „GPRC6A regulates prostate cancer progression”. Prostate 72 (4): 399–409. DOI:10.1002/pros.21442. PMID 21681779.

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GPRC6A

Klinički značaj

Reference

Literatura

Vanjske veze

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