Protein kodiran ovim genom je član familije G protein spregnutih receptora. Ovaj protein je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). On može da aktivira signalizaciju T-ćelijskog faktora. Pokazano je posreduje PGE2 indukovano izražavanje EGR1 faktora, reguliše nivo i stabilnost cikloksigenaze-2 iRNK, i dovodi do fosforilacije glikogen sintaze kinaze-3. Studije na nokaut miševima sugeriraju da ovaj receptor učestvuje u neonatalnoj adaptaciji circulatornog sistema, osteoporozi, kao i inicijaciji kožnog imunskog responsa.[1]
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„Prostanoid Receptors: EP4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
