The 2005–06 KNVB Cup was the 88th edition of the Dutch national football annual knockout tournament for the KNVB Cup. 87 teams contested, beginning on 2 August 2005 and endng at the final on 7 May 2006.
Ajax beat PSV 2–1 in the final, winning the trophy for the sixteenth time.
Both Ajax and PSV already secured a Champions League spot in the national competition. Therefore, the UEFA Cup ticket the winner of this tournament would win, could now be won in the Eredivisie play-offs.