The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Rea (left guard), Resh (center), Moore (right guard), Sherertz (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Gettle (right halfback), Hess (fullback). The substitutes were: Baker, Beck, Dean, Hutcheson, Jones, Linkous, Long and Owens.
The starting lineup for Hampden–Sydney was: Watson (left end), William Fuqua (left tackle), William Saunders (left guard), Edwin Sands (center), Ed Sager (right guard), Robert Stoltz (right tackle), Hugh Brenaman (right end), Ben Smith (quarterback), Bailey Tyson (left halfback), Johnson (right halfback), Rex Blankenship (fullback). The substitutes were: Boynton Breitenhirt, H. S. Buchanan, William Day, M. A. Lush, A. J. McKelway and W. H. Simmerman.
The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Rea (left guard), Resh (center), Moore (right guard), Hutcheson (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Gettle (right halfback), Hess (fullback). The substitutes were: Baker, Beck, Flory, Jones, Rutherford, Sheppard and Sherertz.
The starting lineup for William & Mary was: W. S. Harwood (left end), A. C. Bennett (left tackle), T. J. Young (left guard), John Todd (center), Julius Wilson (right guard), Williams (right tackle), W. S. Sorg (right end), Jack Chalkley (quarterback), Fairmount White (left halfback), Harvey Hastings (right halfback), Thomas Jordan (fullback). The substitutes were: Earnest Dietz, George Flanders, J. C. Fuller, Jones, Paul Keister and Levvy.
The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Rea (left guard), Resh (center), Moore (right guard), Sherertz (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Gettle (right halfback), Hess (fullback). The substitutes were: Flory.
The starting lineup for Centre was: Bradley (left end), Red Roberts (left tackle), George Jones (left guard), Ed Kubale (center), Ben Cregor (right guard), Bill James (right tackle), Minos Gordy (right end), Bo McMillin (quarterback), Thomas Bartlett (left halfback), Norris Armstrong (right halfback), John Tanner (fullback). The substitutes were: Green.
The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Rea (left guard), Resh (center), Sheppard (right guard), Sherertz (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Gettle (right halfback), Hess (fullback). The substitutes were: Baker, Beck, Dean, Flory, Hutcheson, Jones, Moore and Rhodes.
The starting lineup for Richmond was: William Rucker (left end), Graham Carlton (left tackle), Y. M. Hodges (left guard), Ralph Bethel (center), H. S. Johnson (right guard), A. A. Klevesahl (right tackle), C. E. Reams (right end), Thurman Towill (quarterback), Waverly Jones (left halfback), William Ziegler (right halfback), E. Hobson Snead (fullback). The substitutes were: Russell Booker, Crosby, John Fray, McAster, Davis Ratcliffe and Hubel Robins.
The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Rea (left guard), Resh (center), Moore (right guard), Sherertz (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Gettle (right halfback), Hess (fullback). The substitutes were: Flory, Hutcheson, Jones and Rhodes.
The starting lineup for Maryland was: Walter H. Young (left end), Andy Nesbit (left tackle), Mac Brewer (left guard), George Pollock (center), Jesse Gundry (right guard), Joseph C. Burger (right tackle), Cecil Branner (right end), Eddie Semler (quarterback), Brooke Brewer (left halfback), Romeo Pagnucci (right halfback), Jack McQuade (fullback). The substitutes were: John Groves, Lewis and John Moore.
The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Sheppard (left guard), Baker (center), Moore (right guard), Sherertz (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Gettle (right halfback), Hess (fullback). The substitutes were: DeLaBarre, Flory, Linkous, Rea, Resh and Rhodes.
The starting lineup for Washington and Lee was: Thomas Bemis (left end), Lindsay Moore (left tackle), George Vogel (left guard), L. P. Collins (center), W. W. Rangeley (right guard), R. C. Potts (right tackle), Joseph Herndon (right end), Robert Frew (quarterback), D. M. Tucker (left halfback), Marv Mattox (right halfback), J. W. McDonald (fullback). The substitutes were: Bernard Arbogast, Eddie Cameron, J. E. Leake, James Kay Thomas, C. L. Walters and D. P. Wingo.
The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Moore (left guard), Baker (center), Sheppard (right guard), Hutcheson (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Jones (right halfback), Hess (fullback). The substitutes were: Beck, Dean, Rea, Resh, Rhodes and Sherertz.
The starting lineup for NC State was: Samuel Homewood (left end), Averette Floyd (left tackle), Toxey Whitaker (left guard), Thomas Bostian (center), Earl Pasour (right guard), Herbert Weathers (right tackle), William Wearn (right end), J. T. Faucette (quarterback), Nathaniel Pierson (left halfback), Robert Holland (right halfback), Thomas Park (fullback). The substitutes were: David VanSant.
The starting lineup for VPI was: Hardwick (left end), Tilson (left tackle), Sheppard (left guard), Baker (center), Sherertz (right guard), Hutcheson (right tackle), Wilson (right end), Wallace (quarterback), Sutton (left halfback), Gettle (right halfback), Hess (fullback). The substitutes were: Flory, Jones, Rea, Resh and Rhodes.
The starting lineup for VMI was: William Drewry (left end), Frank Summers (left tackle), William Wescott (left guard), Peter Miller (center), William Harrison (right guard), Robert Hunt (right tackle), Ruxton Ridgely (right end), Worthington Faulkner (quarterback), Jere Bunting (left halfback), Hal Costolo (right halfback), William Shannon (fullback). The substitutes were: Attwell, Edwin Clark, Wallace Douglas, Farley, Thomas Gray, Carl Hammond, Edward Ryder, William Venable and Mortimer Watkins.
Players
The following players were members of the 1921 football team according to the roster published in the 1922 edition of The Bugle, the Virginia Tech yearbook.[26]