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早期生长反应蛋白

早期生长反应蛋白early growth response proteins)是一个锌指结构转录因子蛋白家族[1]

其成员包括:EGR1EGR2EGR3EGR4等。其中EGR1属于即早期基因家族成员之一,是参与调控细胞生长英语Cell growth分化以及凋亡的重要转录因子[2],在肝、心、脑、肺、脾、骨骼肌、肾、卵巢和前列腺等组织均可检测到其表达[3]

参考文献

  1. ^ Gómez-Martín D, Díaz-Zamudio M, Galindo-Campos M, Alcocer-Varela J. Early growth response transcription factors and the modulation of immune response: implications towards autoimmunity. Autoimmun Rev. April 2010, 9 (6): 454–8. PMID 20035903. doi:10.1016/j.autrev.2009.12.006. 
  2. ^ BHATTACHARYYA S,FANG F,TOURTELLOTTE W,VARGA J. Egr-1:new conductor for the tissue repair orchestra directs harmony (regeneration)or cacophony(fibrosis)[J]. J Pathol,2013,229 (2):286-297.
  3. ^ FAGERBERG L,HALLSTRÖM BM,OKSVOLD P,KAMPF C,DJUREINOVIC D,ODEBERG J,et al. Analysis of the human tissue- specific expression by genome-wide integration of transcriptomics and antibody-based proteomics[J]. Mol Cell Proteomics,2014,13(2):397-406.

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