ABL2

ABL proto-onkogen 2, nereceptorska tirozinska kinaza
	; PDB prikaz baziran na 1ab2.
Dostupne strukture
	2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH
Identifikatori
Simboli	ABL2; ABLL; ARG
Vanjski ID	OMIM: 164690 MGI: 87860 HomoloGene: 5278 GeneCards: ABL2 Gene
EC broj	2.7.10.2
Ontologija gena
Molekulska funkcija	• vezivanje magnezijumovog jona • vezivanje aktinskog monomera • aktivnost proteinske kinaze
Ćelijska komponenta	• citozol • aktinski citoskeleton
Biološki proces	• proces modifikacije ćelijskih proteina • ćelijska adhezija • prenos signala
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Tirozinska proteinska kinaza ABL2 (Abelsonu srodan gen, Arg) enzim je koji je kod ljudi kodiran ABL2 genom.^[1]^[2]

Funkciја

ABL2 je citoplazmatična tirozinska kinaza koja je blisko srodna sa, mada je distinktna od ABL1. Sličnost ovih proteina obuhvata tirozinske kinazne domene, kao i SH2 i SH3 domene. ABL2 biva izražena u normalnim i tumorskim ćelijama. ABL2 genski produkt se javlja u dve varijante koje imaju različite amino krajeve, duge oko 12-kb.^[2]

Interakcije

ABL2 formira interakcije sa tri proteina: Abl genom,^[3] katalazom,^[4] i SORBS2.^[5] Protein Abl gena je takođe poznat kao abelsonov mišji leukemijski viralni onkogeni homolog 1. On je kod ljudi kodiran kodiran ABL1 genom.^[6] Katalaza je enzim koji katalizuje dekompoziciju vodonik peroksida do vode i kiseonika.^[7] SORBS2 je takođe poznata kao Sorbin i SH3 domen-sadržavajući protein 2. Kod ljudi je ona kodirana SORBS2 genom.^[5]^[8]^[2]

Reference

↑ Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). „A novel human gene closely related to the abl proto-oncogene”. Science 234 (4783): 1545–8. DOI:10.1126/science.3787260. PMID 3787260.
↑ ^2,0 ^2,1 ^2,2 „Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)”. Greška u referenci: Nevaljana oznaka <ref>; naziv "entrez" je zadan više puta s različitim sadržajem
↑ Cao C, Leng Y, Li C, Kufe D (April 2003). „Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response”. J. Biol. Chem. 278 (15): 12961–7. DOI:10.1074/jbc.M300058200. PMID 12569093.
↑ Cao C, Leng Y, Kufe D (August 2003). „Catalase activity is regulated by c-Abl and Arg in the oxidative stress response”. J. Biol. Chem. 278 (32): 29667–75. DOI:10.1074/jbc.M301292200. PMID 12777400.
↑ ^5,0 ^5,1 Wang B, Golemis EA, Kruh GD (July 1997). „ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks”. J. Biol. Chem. 272 (28): 17542–50. DOI:10.1074/jbc.272.28.17542. PMID 9211900. Greška u referenci: Nevaljana oznaka <ref>; naziv "pmid9211900" je zadan više puta s različitim sadržajem
↑ Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). „Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides”. Science 253 (5019): 562–5. DOI:10.1126/science.1857987. PMID 1857987.
↑ Chelikani P, Fita I, Loewen PC (January 2004). „Diversity of structures and properties among catalases”. Cell. Mol. Life Sci. 61 (2): 192–208. DOI:10.1007/s00018-003-3206-5. PMID 14745498.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). „Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res 5 (5): 277–86. DOI:10.1093/dnares/5.5.277. PMID 9872452.

Literatura

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