Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)

Pyridoxal 5′-phosphate synthase (glutamine hydrolysing) (EC 4.3.3.6, PdxST) is an enzyme with systematic name D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5′-phosphate-lyase.^{[1][2][3][4][5][6][7][8]} This enzyme catalyses the following chemical reaction

D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine ${\displaystyle \rightleftharpoons }$ pyridoxal 5′-phosphate + L-glutamate + 3 H₂O + phosphate (overall reaction)

(1a) L-glutamine + H₂O ${\displaystyle \rightleftharpoons }$ L-glutamate + NH₃

(1b) D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH₃ ${\displaystyle \rightleftharpoons }$ pyridoxal 5′-phosphate + 4 H₂O + phosphate

The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate.

• Pyridoxal+5'-phosphate+synthase+(glutamine+hydrolyzing) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)