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List of EC numbers (EC 6)

This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee.^[1] The database is developed and maintained by Andrew McDonald.^[2]

EC 6.1: Forming Carbon-Oxygen Bonds

EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase)

EC 6.1.1.1: tyrosine—tRNA ligase
EC 6.1.1.2: tryptophan—tRNA ligase
EC 6.1.1.3: threonine—tRNA ligase
EC 6.1.1.4: leucine—tRNA ligase
EC 6.1.1.5: isoleucine—tRNA ligase
EC 6.1.1.6: lysine—tRNA ligase
EC 6.1.1.7: alanine—tRNA ligase
EC 6.1.1.8: Deleted
EC 6.1.1.9: valine—tRNA ligase
EC 6.1.1.10: methionine—tRNA ligase
EC 6.1.1.11: serine—tRNA ligase
EC 6.1.1.12: aspartate—tRNA ligase
EC 6.1.1.13: D-alanine—poly(phosphoribitol) ligase
EC 6.1.1.14: glycine—tRNA ligase
EC 6.1.1.15: proline—tRNA ligase
EC 6.1.1.16: cysteine—tRNA ligase
EC 6.1.1.17: glutamate—tRNA ligase
EC 6.1.1.18: glutamine—tRNA ligase
EC 6.1.1.19: arginine—tRNA ligase
EC 6.1.1.20: phenylalanine—tRNA ligase
EC 6.1.1.21: histidine—tRNA ligase
EC 6.1.1.22: asparagine—tRNA ligase
EC 6.1.1.23: aspartate—tRNA^Asn ligase
EC 6.1.1.24: glutamate—tRNA^Gln ligase
EC 6.1.1.25: The tRNA^Pyl is now known only to be charged with pyrrolysine (cf. EC 6.1.1.26)
EC 6.1.1.26: pyrrolysine—tRNA^Pyl ligase
EC 6.1.1.27: O-phospho-L-serine—tRNA ligase
EC 6.1.1.28: "proline/cysteine—tRNA ligase". Later published work having demonstrated that this was not a genuine enzyme, EC 6.1.1.28 was withdrawn at the public-review stage before being made official.

EC 6.1.2: Acid—alcohol ligases (ester synthases)

EC 6.1.3: Cyclo-ligases

EC 6.1.3.1: olefin β-lactone synthetase

EC 6.2: Forming Carbon-Sulfur Bonds

EC 6.2.1: Acid-Thiol Ligases

EC 6.2.2: Amide—thiol ligases

EC 6.3: Forming Carbon-Nitrogen Bonds

EC 6.3.1: Acid—Ammonia (or Amine) Ligases (Amide Synthases)

EC 6.3.1.1: aspartate—ammonia ligase
EC 6.3.1.2: glutamine synthetase
EC 6.3.1.3: Now EC 6.3.4.13, phosphoribosylamine—glycine ligase
EC 6.3.1.4: aspartate—ammonia ligase (ADP-forming)
EC 6.3.1.5: NAD⁺ synthase
EC 6.3.1.6: glutamate—ethylamine ligase
EC 6.3.1.7: 4-methyleneglutamate—ammonia ligase
EC 6.3.1.8: glutathionylspermidine synthase
EC 6.3.1.9: trypanothione synthase
EC 6.3.1.10: adenosylcobinamide-phosphate synthase
EC 6.3.1.11: glutamate—putrescine ligase
EC 6.3.1.12: D-aspartate ligase
EC 6.3.1.13: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase
EC 6.3.1.14: diphthine—ammonia ligase
EC 6.3.1.15: 8-demethylnovobiocic acid synthase
EC 6.3.1.16: [[The enzyme was discovered at the public-review stage to have been misclassified and so was withdrawn. See EC 6.3.3.6, carbapenam-3-carboxylate synthase]]
EC 6.3.1.17: β-citrylglutamate synthase
EC 6.3.1.18: γ-glutamylanilide synthase
EC 6.3.1.19: prokaryotic ubiquitin-like protein ligase
EC 6.3.1.20: lipoate—protein ligase
EC 6.3.1.21: phosphoribosylglycinamide formyltransferase 2

EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)

EC 6.3.2.1: pantoate—β-alanine ligase (AMP-forming)
EC 6.3.2.2: glutamate—cysteine ligase
EC 6.3.2.3: glutathione synthase
EC 6.3.2.4: D-alanine—D-alanine ligase
EC 6.3.2.5: phosphopantothenate—cysteine ligase (CTP)
EC 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase
EC 6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
EC 6.3.2.8: UDP-N-acetylmuramate—L-alanine ligase
EC 6.3.2.9: UDP-N-acetylmuramoyl-L-alanine—D-glutamate ligase
EC 6.3.2.10: UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
EC 6.3.2.11: carnosine synthase
EC 6.3.2.12: dihydrofolate synthase
EC 6.3.2.13: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
EC 6.3.2.14: enterobactin synthase
EC 6.3.2.15: Deleted, The activity observed is due to EC 6.3.2.10, UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
EC 6.3.2.16: D-alanine—alanyl-poly(glycerolphosphate) ligase
EC 6.3.2.17: tetrahydrofolate synthase
EC 6.3.2.18: γ-glutamylhistamine synthase
EC 6.3.2.19: The ubiquitinylation process is now known to be performed by several enzymes in sequence, starting with EC 6.2.1.45 (ubiquitin-activating enzyme E1) and followed by several transfer reactions, including those of EC 2.3.2.23 (E2 ubiquitin-conjugating enzyme) and EC 2.3.2.27 (RING-type E3 ubiquitin transferase)
EC 6.3.2.20: indoleacetate—lysine synthetase
EC 6.3.2.21: [[The reaction is performed by the sequential action of EC 6.2.1.45 (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by EC 2.3.2.27 (ubiquitin transferase RING E3 (calmodulin-selective))|The reaction is performed by the sequential action of EC 6.2.1.45 (ubiquitin-activating enzyme E1), several ubiquitin transferases and finally by EC 2.3.2.27 [ubiquitin transferase RING E3 (calmodulin-selective)]]]
EC 6.3.2.22: Now EC 6.3.1.14, diphthine—ammonia ligase.
EC 6.3.2.23: homoglutathione synthase
EC 6.3.2.24: tyrosine—arginine ligase
EC 6.3.2.25: tubulin—tyrosine ligase
EC 6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
EC 6.3.2.27: [[The activity is covered by two independent enzymes, EC 6.3.2.38 N^2-citryl-N^6-acetyl-N^6-hydroxylysine synthase, and EC 6.3.2.39, aerobactin synthase|The activity is covered by two independent enzymes, EC 6.3.2.38 N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase, and EC 6.3.2.39, aerobactin synthase]]
EC 6.3.2.28: Now EC 6.3.2.49, L-alanine-L-anticapsin ligase
EC 6.3.2.29: cyanophycin synthase (L-aspartate-adding)
EC 6.3.2.30: cyanophycin synthase (L-arginine-adding)
EC 6.3.2.31: coenzyme F₄₂₀-0:L-glutamate ligase
EC 6.3.2.32: coenzyme γ-F₄₂₀-2:α-L-glutamate ligase
EC 6.3.2.33: tetrahydrosarcinapterin synthase
EC 6.3.2.34: coenzyme F₄₂₀-0:L-glutamate ligase
EC 6.3.2.35: D-alanine—D-serine ligase
EC 6.3.2.36: 4-phosphopantoate—β-alanine ligase
EC 6.3.2.37: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
EC 6.3.2.38: N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase
EC 6.3.2.39: aerobactin synthase
EC 6.3.2.40: cyclopeptine synthase
EC 6.3.2.41: N-acetylaspartylglutamate synthase
EC 6.3.2.42: N-acetylaspartylglutamylglutamate synthase
EC 6.3.2.43: [amino-group carrier protein]—L-2-aminoadipate ligase
EC 6.3.2.44: pantoate—β-alanine ligase (ADP-forming)
EC 6.3.2.45: UDP-N-acetylmuramate—L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
EC 6.3.2.46: fumarate—(S)-2,3-diaminopropanoate ligase
EC 6.3.2.47: dapdiamide synthase
EC 6.3.2.48: L-arginine-specific L-amino acid ligase
EC 6.3.2.49: L-alanine—L-anticapsin ligase
EC 6.3.2.50: tenuazonic acid synthetase
EC 6.3.2.51: phosphopantothenate—cysteine ligase (ATP)
EC 6.3.2.52: jasmonoyl—L-amino acid ligase
EC 6.3.2.53: UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase
EC 6.3.2.54: L-2,3-diaminopropanoate—citrate ligase
EC 6.3.2.55: 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
EC 6.3.2.56: staphyloferrin B synthase
EC 6.3.2.57: staphyloferrin A synthase
EC 6.3.2.58: D-ornithine—citrate ligase
EC 6.3.2.59: 3-methyl-D-ornithine—L-lysine ligase
EC 6.3.2.60: glutamate—[amino group carrier protein] ligase
EC 6.3.2.61: tubulin-glutamate ligase
EC 6.3.2.62: β-tubulin-glutamate ligase

EC 6.3.3: Cyclo-Ligases

EC 6.3.4: Other Carbon-Nitrogen Ligases

EC 6.3.5: Carbon-nitrogen ligases with glutamine as amido-N-donor

EC 6.3.5.1: NAD⁺ synthase (glutamine-hydrolysing)
EC 6.3.5.2: GMP synthase (glutamine-hydrolysing)
EC 6.3.5.3: phosphoribosylformylglycinamidine synthase
EC 6.3.5.4: asparagine synthase (glutamine-hydrolysing)
EC 6.3.5.5: carbamoyl-phosphate synthase (glutamine-hydrolysing)
EC 6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)
EC 6.3.5.7: glutaminyl-tRNA synthase (glutamine-hydrolysing)
EC 6.3.5.8: Now EC 2.6.1.85, aminodeoxychorismate synthase. As ATP is not hydrolysed during the reaction, the classification of the enzyme as a ligase was incorrect
EC 6.3.5.9: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
EC 6.3.5.10: adenosylcobyric acid synthase (glutamine-hydrolysing)
EC 6.3.5.11: cobyrinate a,c-diamide synthase
EC 6.3.5.12: Ni-sirohydrochlorin a,c-diamide synthase
EC 6.3.5.13: lipid II isoglutaminyl synthase (glutamine-hydrolysing)

EC 6.4: Forming Carbon-Carbon Bonds

EC 6.4.1: Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

EC 6.5: Forming Phosphoric Ester Bonds

EC 6.5.1: Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)

EC 6.6: Forming Nitrogen-Metal Bonds

EC 6.6.1: Forming Coordination Complexes

EC 6.7: Forming nitrogen-nitrogen bonds

EC 6.7.1: Forming diazo bonds

EC 6.7.1.1: 3-amino-2-hydroxy-4-methoxybenzoate

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

v t e Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-Alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase 2-furoate—CoA ligase 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase 3-hydroxybenzoate—CoA ligase 3-hydroxypropionyl-CoA synthase 4-chlorobenzoate—CoA ligase 4-Coumarate-CoA ligase 4-hydroxybenzoate—CoA ligase 6-carboxyhexanoate—CoA ligase Acetate—ACP ligase Acetate—CoA ligase (ADP-forming) Acetoacetate—CoA ligase Acetyl—CoA synthetase Acid—CoA ligase (GDP-forming) Anthranilate—CoA ligase Arachidonate—CoA ligase Benzoate—CoA ligase Biotin—CoA ligase (butirosin acyl-carrier protein)—L-glutamate ligase Butyrate—CoA ligase Cholate—CoA ligase Citrate—CoA ligase (citrate (pro-3S)-lyase) ligase Dicarboxylate—CoA ligase Glutarate—CoA ligase Long-chain-fatty-acid—ACP ligase Long-chain-fatty-acid—CoA ligase Malate—CoA ligase Malonate—CoA ligase o-Succinylbenzoate—CoA ligase Oxalate—CoA ligase Phenylacetate—CoA ligase Phytanate—CoA ligase Propionate—CoA ligase Succinate—CoA ligase (ADP-forming) Succinate—CoA ligase (GDP-forming) Succinyl—CoA synthetase trans-Feruloyl—CoA synthase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

v t e Ligases: carbon-carbon ligases (EC 6.4)
Biotin dependent carboxylation	Pyruvate carboxylase Acetyl-CoA carboxylase Propionyl-CoA carboxylase Methylcrotonyl-CoA carboxylase
Other	Polyketide synthase

References

^ "ExplorEnz – The Enzyme Database".
^ McDonald, A.G.; Boyce, S.; K.F., Tipton (2009). "ExplorEnz: the primary source of the IUBMB enzyme list". Nucleic Acids Res. 37 (Database issue): D593 – D597. doi:10.1093/nar/gkn582. PMC 2686581. PMID 18776214.

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Prefix: a b c d e f g h i j k l m n o p q r s t u v w x y z 0 1 2 3 4 5 6 7 8 9

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