Ilaprazol

Ilaprazol
Nama sistematis (IUPAC)
	2-[(RS)-[(4-metoksi-3-metilpiridin-2-il)metil]sulfinil]-5-(1H-pirol-1-il)-1H-benzimidazola
Data klinis
Nama dagang	Lylian, Noltec
Kat. kehamilan	?
Status hukum	?
Rute	Oral
Pengenal
Nomor CAS	172152-36-2
Kode ATC	A02BC11
PubChem	CID 214351
ChemSpider	185839
UNII	776Q6XX45J
KEGG	D13013
ChEMBL	CHEMBL2106370
Data kimia
Rumus	C19H18N4O2S
SMILES	eMolecules & PubChem
	InChI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22); Key:HRRXCXABAPSOCP-UHFFFAOYSA-N;

Ilaprazol (nama dagang Noltec) adalah penghambat pompa proton (PPI) yang digunakan dalam pengobatan dispepsia, penyakit tukak lambung (PUD), penyakit refluks gastroesofagus (GORD/GERD)^[1] dan tukak duodenum.^[2]^[3]

Obat ini tersedia dalam kekuatan 5, 10, dan 20 mg.

Studi klinis menunjukkan bahwa ilaprazol setidaknya merupakan PPI yang sama kuatnya dengan omeprazol jika dikonsumsi dalam dosis yang setara. Studi juga menunjukkan bahwa ilaprazol secara signifikan mencegah perkembangan esofagitis refluks.

Ilaprazol dikembangkan oleh Il-Yang Pharmaceutical (Korea), dan masih dalam uji klinis dengan FDA AS. Obat ini telah diluncurkan di Korea dan Cina untuk pengobatan tukak lambung, tukak duodenum, penyakit refluks gastroesofagus]], dan esofagitis erosif.^[4]

Referensi

^ Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy. 17 (15): 2107–13. doi:10.1080/14656566.2016.1232389. PMID 27598861. S2CID 38638311.
^ Bohidar NP, Krishna K, Panda BK, Patel C (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology. 34 (2): 95–8. doi:10.7869/tg.2012.105. PMID 24377157.
^ Ji XQ, Du JF, Chen G, Chen G, Yu B (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology. 20 (17): 5119–23. doi:10.3748/wjg.v20.i17.5119. PMC 4009550. PMID 24803828.
^ Nomor uji klinis NCT00952978 for "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)" di ClinicalTrials.gov

[Savarino_2016-1] Savarino E, Ottonello A, Martinucci I, Dulbecco P, Savarino V (October 2016). "Ilaprazole for the treatment of gastro-esophageal reflux". Expert Opinion on Pharmacotherapy. 17 (15): 2107–13. doi:10.1080/14656566.2016.1232389. PMID 27598861. S2CID 38638311.

[Bohidar_2013-2] Bohidar NP, Krishna K, Panda BK, Patel C (2013). "Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer?". Tropical Gastroenterology. 34 (2): 95–8. doi:10.7869/tg.2012.105. PMID 24377157.

[Ji_2014-3] Ji XQ, Du JF, Chen G, Chen G, Yu B (May 2014). "Efficacy of ilaprazole in the treatment of duodenal ulcers: a meta-analysis". World Journal of Gastroenterology. 20 (17): 5119–23. doi:10.3748/wjg.v20.i17.5119. PMC 4009550. PMID 24803828.

[NCT00952978-4] Nomor uji klinis NCT00952978 for "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)" di ClinicalTrials.gov

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Ilaprazol

Referensi

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