TAS2R4

Receptor ukusa tip 2 član 4
Receptor ukusa tip 2 član 4
Identifikatori
Simboli	TAS2R4; T2R4
Vanjski ID	OMIM: 604869 MGI: 2681210 HomoloGene: 49480 IUPHAR: GeneCards: TAS2R4 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa;
Celularna komponenta	• integralno sa membranom;
Biološki proces	• signalni put G-protein spregnutog receptora; • hemosensorno ponašanje; • detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji ukusa;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	50832
Ensembl	ENSG00000127364
UniProt	Q9NYW5
RefSeq (mRNA)	NM_016944.1
RefSeq (protein)	NP_058640.1
Lokacija (UCSC)	Chr 7:; 141.48 - 141.48 Mb
PubMed pretraga	[1]

Receptor ukusa tip 2 član 4 je protein koji je kod ljudi kodiran TAS2R4 genom.^[1]^[2]^[3]

Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Ovaj receptor ukusa ne sadrži introne. Njegov gen se nalazi na hromozomu 7.^[3]

Reference

^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). „A novel family of mammalian taste receptors”. Cell. 100 (6): 693—702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9.
^ Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). „T2Rs function as bitter taste receptors”. Cell. 100 (6): 703—11. PMID 10761935. doi:10.1016/S0092-8674(00)80706-0.
^ ^а ^б „Entrez Gene: TAS2R4 taste receptor, type 2, member 4”.

Literatura

Kinnamon SC (2000). „A plethora of taste receptors”. Neuron. 25 (3): 507—10. PMID 10774719. doi:10.1016/S0896-6273(00)81054-5.
Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
Firestein S (2000). „The good taste of genomics”. Nature. 404 (6778): 552—3. PMID 10766221. doi:10.1038/35007167.
Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse”. Nature. 404 (6778): 601—4. PMID 10766242. doi:10.1038/35007072.
Ueda T; Ugawa S; Ishida Y; et al. (2001). „Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting”. Biochem. Biophys. Res. Commun. 285 (1): 147—51. PMID 11437385. doi:10.1006/bbrc.2001.5136.
Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.

Vidi još

Receptor ukusa

[pmid10761934-1] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). „A novel family of mammalian taste receptors”. Cell. 100 (6): 693—702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9.

[pmid10761935-2] Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). „T2Rs function as bitter taste receptors”. Cell. 100 (6): 703—11. PMID 10761935. doi:10.1016/S0092-8674(00)80706-0.

[entrez-3] а ^б „Entrez Gene: TAS2R4 taste receptor, type 2, member 4”.

[1]

[2]

[3]

TAS2R4

Reference

Literatura

Vidi još

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