Deferipron

Deferipron
Klinički podaci
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	1,9 h
Izlučivanje	Renalno
Identifikatori
CAS broj	30652-11-0
ATC kod	V03AC02 (WHO)
PubChem	CID 2972
DrugBank	DB08826
ChemSpider	2866
ChEBI	CHEBI:68554
ChEMBL	CHEMBL70927
Hemijski podaci
Formula	C7H9NO2
Molarna masa	139,152
	SMILES CN1C=CC(=O)C(O)=C1C; ;
	InChI InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3 ; Key:TZXKOCQBRNJULO-UHFFFAOYSA-N ;

Deferipron je organsko jedinjenje, koje sadrži 7 atoma ugljenika i ima molekulsku masu od 139,152 Da.^[1]^[2]^[3]^[4]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	1
Broj rotacionih veza	0
Particioni koeficijent^[5] (ALogP)	-0,1
Rastvorljivost^[6] (logS, log(mol/L))	-0,4
Polarna površina^[7] (PSA, Å²)	40,5

Reference

^ Roberts DJ, Brunskill SJ, Doree C, Williams S, Howard J, Hyde CJ: Oral deferiprone for iron chelation in people with thalassaemia. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004839. Roberts, D. J.; Brunskill, S. J.; Doree, C.; Williams, S.; Howard, J.; Hyde, C. J. (2007). Roberts, David, ур. „Oral deferiprone for iron chelation in people with thalassaemia”. The Cochrane Database of Systematic Reviews (3): CD004839. PMID 17636775. doi:10.1002/14651858.CD004839.pub2.
^ Victor Hoffbrand A: Deferiprone therapy for transfusional iron overload. Victor Hoffbrand, A. (јун 2005). „Deferiprone therapy for transfusional iron overload”. Best Pract Res Clin Haematol. 18 (2): 299—317. PMID 15737892. doi:10.1016/j.beha.2004.08.026.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.