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Trimerlizin II

Trimerlizin II
Identifikatori
EC broj 3.4.24.53
CAS broj 151125-15-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Trimerlizin II (EC 3.4.24.53, Trimeresurus metaloendopeptidaza II, proteinaza H2, H2-proteinaza) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje Asn3-Gln, His10-Leu i Ala14-Leu u lancu insulina B, i veze Z-Gly-Pro-Leu-Gly-Pro malim molekulima koji su supstrati mikrobne kolagenaze

Ova nehemoragična endopeptidaza je prisutna u venumu zmije Trimeresurus flavoviridis.

Reference

  1. Takahashi, T. and Ohsaka, A. (1970). „Purification and characterization of a proteinase in the venom of Trimeresurus flavoviridis. Complete separation of the enzyme from hemorrhagic activity”. Biochim. Biophys. Acta 198: 293-307. PMID 4984550. 
  2. Takeya, H., Arakawa, M., Miyata, T., Iwanaga, S. and Omori-Satoh, T. (1989). „Primary structure of H2-proteinase, a non-hemorrhagic metalloproteinase, isolated from the venom of the habu snake, Trimeresurus flavoviridis”. J. Biochem. (Tokyo) 106: 151-157. PMID 2777746. 

Literatura

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