UGT2A2

UGT2A2
Identifiers
Aliases	UGT2A2, UDP glucuronosyltransferase family 2 member A2, UDPGT 2A2
External IDs	MGI: 3576095; HomoloGene: 115736; GeneCards: UGT2A2; OMA:UGT2A2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	69,639,642 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,630,119 bp
RNA expression pattern
	Top expressed in
	testicle; ; olfactory zone of nasal mucosa; ; right lobe of liver; ; anterior pituitary; ; human kidney; ; renal cortex; ; skin of abdomen; ; skin of leg; ; vagina; ; wall of uterus;
	Top expressed in
	respiratory epithelium; ; olfactory epithelium; ; duodenum; ; hepatobiliary system; ; liver; ; jejunum; ; olfactory bulb; ; integument; ; skin; ; human kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; glucuronosyltransferase activity; hexosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; membrane;
Biological process	sensory perception of smell; detection of chemical stimulus; cellular glucuronidation; response to stimulus; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	574537
	552899
	ENSG00000271271
	ENSMUSG00000029268
	Q9Y4X1
	Q6PDD0
	NM_001301233; NM_001105677
	NM_001024148
NP_001099147; NP_001288162; NP_001239203; NP_001239204; NP_001288168;
	NP_006789
	NP_001019319
	Wikidata
View/Edit Human	View/Edit Mouse

UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.^[5]^[6]

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.^[5] UGT2A1 and UGT2A2 were recently implicated as having a role in the loss of smell symptom associated with COVID-19.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000271271 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029268 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".
^ Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, et al. (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenetics and Genomics. 15 (10): 677–685. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793.
^ Shelton JF, Shastri AJ, Aslibekyan S, Auton A, et al. (23andMe COVID-19 Team) (2021). "The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia | medRxiv". medRxiv 10.1101/2021.05.28.21257993v1.