Biological phenomenon
Principle of transcriptional memory. A pulse of an inducer (priming) results in expression of target genes, which subsides upon withdrawal. During a window of no induction (window of memory), some genes maintain a poised but transcriptionally silent state that results in a stronger gene activation upon a second challenge. Transcriptional memory is a biological phenomenon, initially discovered in yeast,[ 1] [ 1] [ 2] [ 3] [ 4] [ 5] [ 6] LPS [ 7] interferon [ 8] [ 9] [ 10] chromatin may contribute to the poised transcriptional state allowing faster re-induction. These include: activity of specific transcription factors,[ 11] [ 12] [ 13] RNA polymerase II at the promoters of poised genes,[ 9] chromatin remodeling complexes,[ 2] [ 8] [ 13] H3K36me3 [ 10] histone modifications , occupancy of the H3.3 histone variant ,[ 10] nuclear pore components.[ 9] [ 14] cohesin was shown to inhibit establishment of transcriptional memory in human cells during interferon gamma stimulation.[ 15]
References
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"Epigenetic Transcriptional Memory of GAL Genes Depends on Growth in Glucose and the Tup1 Transcription Factor in Saccharomyces cerevisiae" . Genetics . 206 (4): 1895– 1907. doi :10.1534/genetics.117.201632 . ISSN 1943-2631 . PMC 5560796 PMID 28607146 . ^ a b Lämke, Jörn; Brzezinka, Krzysztof; Altmann, Simone; Bäurle, Isabel (2016-01-18). "A hit-and-run heat shock factor governs sustained histone methylation and transcriptional stress memory" . The EMBO Journal . 35 (2): 162– 175. doi :10.15252/embj.201592593 . ISSN 1460-2075 . PMC 4718455 PMID 26657708 . ^ Pascual-Garcia, Pau; Debo, Brian; Aleman, Jennifer R.; Talamas, Jessica A.; Lan, Yemin; Nguyen, Nha H.; Won, Kyoung J.; Capelson, Maya (2017-04-06). "Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts" . Molecular Cell . 66 (1): 63–76.e6. doi :10.1016/j.molcel.2017.02.020 ISSN 1097-4164 . 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