TPM domain

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The TPM domain family is named after the three founding proteins TLP18.3, Psb32 and MOLO-1. TPM domains have a characteristic alpha-helical fold (αβαβαββαα^[1] or βαβαββαα^[2]) and (3+3^[1] or 2+3^[2]) flanking four central β strands. The TPM fold has not been found in other protein domains to date. TPM was previously referred to as "DUF477" and "Repair_PSII".

In plants, the TPM domain-containing proteins TLP18.3 and Psb32 have been implicated the photosystem II (PSII) repair cycle. It may be involved in the regulation of synthesis/degradation of the D1 protein of the PSII core and in the assembly of PSII monomers into dimers in the grana stacks.^[3]

In the model nematode C. elegans, the MOLO-1 protein is an auxiliary subunit that positively modulates the gating of levamisole-sensitive acetylcholine receptors.^[4]