Williams’s result that the complexity class NEXP is not contained in ACC0 received the best paper award at the Conference on Computational Complexity in 2011.[6] Complexity theorist Scott Aaronson has called the result "one of the most spectacular of the decade".[7] In 2024, for this work Williams was awarded the Gödel Prize.
Williams has also worked on the computational complexity of k-anonymity.[8]
In 2025, Williams, leveraging previous work of J. Cook and I. Mertz[9] on catalytic computing, proved that every deterministic multitape Turing machine of time complexity can be simulated in space ,[10] improving the previous bound of by Hopcroft, Paul, and Valiant,[11] and strengthening the case in the negative for the question if PSPACE=P.[12]
Meyerson, Adam; Williams, Ryan (2004), "On the complexity of optimal k-anonymity", Proceedings of the Twenty-Third ACM SIGMOD-SIGACT-SIGART Symposium on Principles of Database Systems (PODS '04), New York, NY, USA: ACM, pp. 223–228, doi:10.1145/1055558.1055591, ISBN978-1581138580, S2CID6798963
Williams, R. (2005), "Better Time-Space Lower Bounds for SAT and Related Problems", IEEE Conference on Computational Complexity (CCC), pp. 40–49
^Proceedings of 20th Annual IEEE Conference on Computational Complexity (CCC'05)
San Jose, CA June 11-June 15, ISBN0-7695-2364-1, and Twenty-Second Annual IEEE Conference on Computational Complexity (CCC'07)
San Diego, California, June 13-March 16, ISBN0-7695-2780-9.