Gene of the species Homo sapiens
Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene .[ 4] [ 5] [ 6]
Interactions
RIMS2 has been shown to interact with YWHAH ,[ 7] RAPGEF4 ,[ 8] [ 9] UNC13A .[ 10]
References
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037386 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (5): 277– 86. doi :10.1093/dnares/5.5.277 PMID 9872452 . ^ Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2" . J Biol Chem . 278 (17): 15373– 80. doi :10.1074/jbc.M212341200 PMID 12578829 . ^ "Entrez Gene: RIMS2 regulating synaptic membrane exocytosis 2" .^ Sun, Lei; Bittner Mary A; Holz Ronald W (October 2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus" . J. Biol. Chem . 278 (40). United States: 38301– 9. doi :10.1074/jbc.M212801200 ISSN 0021-9258 . PMID 12871946 . ^ Shibasaki, Tadao; Sunaga Yasuhiro; Fujimoto Kei; Kashima Yasushige; Seino Susumu (February 2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis" . J. Biol. Chem . 279 (9). United States: 7956– 61. doi :10.1074/jbc.M309068200 ISSN 0021-9258 . PMID 14660679 . ^ Kashima, Y; Miki T; Shibasaki T; Ozaki N; Miyazaki M; Yano H; Seino S (Dec 2001). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion" . J. Biol. Chem . 276 (49). United States: 46046– 53. doi :10.1074/jbc.M108378200 ISSN 0021-9258 . PMID 11598134 . ^ "Protein unc-13 homolog A" . UniProt .
Further reading
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107– 13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353– 8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Fenster SD, Chung WJ, Zhai R, et al. (2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon" . Neuron . 25 (1): 203– 14. doi :10.1016/S0896-6273(00)80883-1 PMID 10707984 . S2CID 10177138 . Kashima Y, Miki T, Shibasaki T, et al. (2002). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion" . J. Biol. Chem . 276 (49): 46046– 53. doi :10.1074/jbc.M108378200 PMID 11598134 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Wang Y, Südhof TC (2003). "Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins( small star, filled )". Genomics . 81 (2): 126– 37. doi :10.1016/S0888-7543(02)00024-1 . PMID 12620390 . Sun L, Bittner MA, Holz RW (2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus" . J. Biol. Chem . 278 (40): 38301– 9. doi :10.1074/jbc.M212801200 PMID 12871946 . Shibasaki T, Sunaga Y, Fujimoto K, et al. (2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis" . J. Biol. Chem . 279 (9): 7956– 61. doi :10.1074/jbc.M309068200 PMID 14660679 . Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707– 16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Res . 14 (9): 1711– 8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gérard HC, Whittum-Hudson JA, Schumacher HR, Hudson AP (2006). "Synovial Chlamydia trachomatis up regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection" . Ann. Rheum. Dis . 65 (3): 321– 7. doi :10.1136/ard.2005.042226 . PMC 1798071 PMID 16192289 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
PDB gallery
1v27 : Solution structure of the first C2 domain of RIM2
1wfg : PDZ domain of human RIM2B
2bwq : CRYSTAL STRUCTURE OF THE RIM2 C2A-DOMAIN AT 1.4 ANGSTROM RESOLUTION
