Protein-coding gene in the species Homo sapiens
Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene .[ 5] [ 6] [ 7]
Function
RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac .[ 6] CPC ), and to activate the catalytic component of the CPC, Aurora B , in the presence of microtubules .[ 8] [ 9]
References
^ a b c ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040945 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (2): 143– 50. doi :10.1093/dnares/7.2.143 PMID 10819331 . ^ a b Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression" . Dev Cell . 5 (2): 295– 307. doi :10.1016/S1534-5807(03)00205-3 PMID 12919680 . ^ "Entrez Gene: RCC2 regulator of chromosome condensation 2" .^ Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (July 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle" . J. Cell Biol . 166 (2): 179– 91. doi :10.1083/jcb.200404001 . PMC 2172304 PMID 15249581 . ^ Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science . 319 (5862): 469– 72. Bibcode :2008Sci...319..469R . doi :10.1126/science.1148980 . PMID 18218899 . S2CID 10374348 .
Further reading
Andreassen PR, Palmer DK, Wener MH, Margolis RL (1991). "Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis" . J. Cell Sci . 99 (3): 523– 34. doi :10.1242/jcs.99.3.523 PMID 1939370 . Martineau SN, Andreassen PR, Margolis RL (1995). "Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery" . J. Cell Biol . 131 (1): 191– 205. doi :10.1083/jcb.131.1.191 . PMC 2120587 PMID 7559776 . Martineau-Thuillier S, Andreassen PR, Margolis RL (1999). "Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis". Chromosoma . 107 (6– 7): 461– 70. doi :10.1007/s004120050330 . PMID 9914378 . S2CID 24935187 . Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus" . Mol. Biol. Cell . 13 (11): 4100– 9. doi :10.1091/mbc.E02-05-0271 . PMC 133617 PMID 12429849 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gassmann R, Carvalho A, Henzing AJ, et al. (2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle" . J. Cell Biol . 166 (2): 179– 91. doi :10.1083/jcb.200404001 . PMC 2172304 PMID 15249581 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Rosasco-Nitcher, Sara; Lan W; Khorasanizadeh S; Stukenberg PT. (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science . 319 (5862): 469– 472. Bibcode :2008Sci...319..469R . doi :10.1126/science.1148980 . PMID 18218899 . S2CID 10374348 .
External links
