Protein-coding gene in the species Homo sapiens
Placenta specific 8 is a protein that in humans is encoded by the PLAC8 gene .
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References
Further reading
Wu SF, Huang Y, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ (2010). "The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation". Leukemia . 24 (3): 544– 51. doi :10.1038/leu.2009.280 . PMID 20072156 . S2CID 205193718 . Mourtada-Maarabouni M, Watson D, Munir M, Farzaneh F, Williams GT (2013). "Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types". Curr Cancer Drug Targets . 13 (1): 80– 91. doi :10.2174/156800913804486584 . PMID 22920440 . Uehara H, Takahashi T, Izumi K (2013). "Induction of retinol-binding protein 4 and placenta-specific 8 expression in human prostate cancer cells remaining in bone following osteolytic tumor growth inhibition by osteoprotegerin" . Int. J. Oncol . 43 (2): 365– 74. doi :10.3892/ijo.2013.1954 . PMC 3775580 PMID 23708710 . Li C, Ma H, Wang Y, Cao Z, Graves-Deal R, Powell AE, Starchenko A, Ayers GD, Washington MK, Kamath V, Desai K, Gerdes MJ, Solnica-Krezel L, Coffey RJ (2014). "Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer" . J. Clin. Invest . 124 (5): 2172– 87. doi :10.1172/JCI71103 . PMC 4001536 PMID 24691442 . Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H (2014). "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression" . Cell Rep . 7 (4): 1143– 55. doi :10.1016/j.celrep.2014.03.061 . PMC 4112575 PMID 24794439 . Blue EK, Sheehan BM, Nuss ZV, Boyle FA, Hocutt CM, Gohn CR, Varberg KM, McClintick JN, Haneline LS (2015). "Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus" . Diabetes . 64 (7): 2664– 75. doi :10.2337/db14-1709 . PMC 4477353 PMID 25720387 . Kaistha BP, Lorenz H, Schmidt H, Sipos B, Pawlak M, Gierke B, Kreider R, Lankat-Buttgereit B, Sauer M, Fiedler L, Krattenmacher A, Geisel B, Kraus JM, Frese KK, Kelkenberg S, Giese NA, Kestler HA, Gress TM, Buchholz M (2016). "PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways" . Cancer Res . 76 (1): 96– 107. doi :10.1158/0008-5472.CAN-15-0216 PMID 26669866 . Li M, Liu D, Wang L, Wang W, Wang A, Yao Y (2016). "Expression of placenta-specific 8 in human oocytes, embryos, and models of in vitro implantation" . Fertil. Steril . 106 (3): 781–789.e2. doi :10.1016/j.fertnstert.2016.05.018 PMID 27322877 .
