Protein-coding gene in humans
Phosducin-like protein is a protein that in humans is encoded by the PDCL gene .[ 5] [ 6]
Phosducin-like protein is a putative modulator of heterotrimeric G proteins . The protein shares extensive amino acid sequence homology with phosducin , a phosphoprotein expressed in the retina and pineal gland . Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000136940 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009030 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Thibault C, Feng Wang J, Charnas R, Mirel D, Barhite S, Miles MF (May 1999). "Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization". Biochim Biophys Acta . 1444 (3): 346– 54. doi :10.1016/S0167-4781(99)00006-8 . PMID 10095058 . ^ a b "Entrez Gene: PDCL phosducin-like" .
Further reading
Miles MF, Barhite S, Sganga M, Elliott M (1993). "Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function" . Proc. Natl. Acad. Sci. U.S.A . 90 (22): 10831– 5. Bibcode :1993PNAS...9010831M . doi :10.1073/pnas.90.22.10831 PMC 47872 PMID 8248177 . Lazarov ME, Martin MM, Willardson BM, Elton TS (1999). "Human phosducin-like protein (hPhLP) messenger RNA stability is regulated by cis-acting instability elements present in the 3'-untranslated region". Biochim. Biophys. Acta . 1446 (3): 253– 64. doi :10.1016/S0167-4781(99)00098-6 . PMID 10524200 . Ruiz-Gómez A, Humrich J, Murga C, et al. (2000). "Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2" . J. Biol. Chem . 275 (38): 29724– 30. doi :10.1074/jbc.M001864200 PMID 10884381 . Lazarov ME, Martin MM, Willardson BM, Elton TS (2000). "Molecular cloning and characterization of the human phosducin-like protein (hPhLP) promoter". Biochim. Biophys. Acta . 1492 (2– 3): 460– 4. doi :10.1016/S0167-4781(00)00137-8 . PMID 10899582 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788– 95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422– 35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287– 92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . McLaughlin JN, Thulin CD, Hart SJ, et al. (2002). "Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex" . Proc. Natl. Acad. Sci. U.S.A . 99 (12): 7962– 7. Bibcode :2002PNAS...99.7962M . doi :10.1073/pnas.112075699 PMC 123003 PMID 12060742 . Humrich J, Bermel C, Grubel T, et al. (2003). "Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing" . J. Biol. Chem . 278 (7): 4474– 81. doi :10.1074/jbc.M206347200 PMID 12466282 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136– 44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Carter MD, Southwick K, Lukov G, et al. (2005). "Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry" . J Biomol Tech . 15 (4): 257– 64. PMC 2291704 PMID 15585822 . Humrich J, Bermel C, Bünemann M, et al. (2005). "Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding" . J. Biol. Chem . 280 (20): 20042– 50. doi :10.1074/jbc.M409233200 PMID 15745879 . Lukov GL, Hu T, McLaughlin JN, et al. (2005). "Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly" . EMBO J . 24 (11): 1965– 75. doi :10.1038/sj.emboj.7600673 . PMC 1142607 PMID 15889144 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Lukov GL, Baker CM, Ludtke PJ, et al. (2006). "Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex" . J. Biol. Chem . 281 (31): 22261– 74. doi :10.1074/jbc.M601590200 PMID 16717095 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635– 48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
