Protein-coding gene in the species Homo sapiens
Proline/serine-rich coiled-coil protein 1 is a protein that in humans is encoded by the PSRC1 gene .[ 5] [ 6] [ 7]
This gene encodes a proline -rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000134222 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068744 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta . 1579 (2– 3): 214– 8. doi :10.1016/s0167-4781(02)00512-2 . PMID 12427559 . ^ Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3" . Oncogene . 18 (54): 7765– 74. doi :10.1038/sj.onc.1203167 PMID 10618717 . ^ a b "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1" .
Further reading
Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans" . Nat. Genet . 40 (2): 189– 97. doi :10.1038/ng.75 . PMC 2682493 PMID 18193044 . Wallace C, Newhouse SJ, Braund P, et al. (2008). "Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia" . Am. J. Hum. Genet . 82 (1): 139– 49. doi :10.1016/j.ajhg.2007.11.001 . PMC 2253977 PMID 18179892 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285– 92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315– 21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression" . Proc. Natl. Acad. Sci. U.S.A . 101 (44): 15724– 9. Bibcode :2004PNAS..10115724W . doi :10.1073/pnas.0404089101 PMC 524842 PMID 15498874 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 .
