PRO 2000

PRO 2000
Clinical data
Other names	2-Naphthalenesulfonic acid, sodium salt, polymer with formaldehyde
Identifiers
	IUPAC name Sodium 2-naphthalenesulfonate, polymer with formaldehyde;
CAS Number	29321-75-3;
ChemSpider	none;
NIAID ChemDB	032942;
CompTox Dashboard (EPA)	DTXSID401011472 ;
ECHA InfoCard	100.111.201
Chemical and physical data
Formula	(C10H8O3S.CH2O.Na)x
Molar mass	Approximately 5 kg/mol

PRO 2000 is an experimental vaginal microbicide which has been proposed as a preventive medicine for reducing the risk of contracting HIV. It has never been recommended as an effective medicine to be used for any purpose. Some clinical trials have shown that under some conditions it may provide some protection against HIV.

History

Endo Pharmaceuticals manufactures the drug.^[1]

Efficacy

Animal testing studies done on macaques have shown that PRO 2000 is effective in preventing the transmission of HIV. Other studies have given supportive evidence that the product is safe in humans and would be an appropriate candidate for testing.^[2]

A phase III clinical trial of 9385 women in sub-Saharan Africa showed that PRO 2000 was not effective in preventing transmission of HIV.^[3]