Plexin-A2 is a protein that in humans is coded by the PLXNA2gene.[5][6]
This gene encodes a member of the plexin-A family of semaphorinco-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[6]
In some studies, the PLXNA2 gene is associated with schizophrenia.[7] and anxiety. PLXNA2 is a candidate gene for intellectual disability and possibly facial dysmorphism and congenital heart disease[8][9]
^Altuame FD, Shamseldin HE, Albatti TH, Hashem M, Ewida N, Abdulwahab F, Alkuraya FS (July 2021). "PLXNA2 as a candidate gene in patients with intellectual disability". American Journal of Medical Genetics. Part A. 185 (12): 3859–3865. doi:10.1002/ajmg.a.62440. PMID34327814. S2CID236516392.
Fujii T, Iijima Y, Kondo H, et al. (2007). "Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (4): 873–7. doi:10.1016/j.pnpbp.2007.01.027. PMID17346868. S2CID46003583.
