NDRG4

NDRG4
Identifiers
Aliases	NDRG4, BDM1, SMAP-8, SMAP8, NDRG family member 4
External IDs	OMIM: 614463; MGI: 2384590; HomoloGene: 23228; GeneCards: NDRG4; OMA:NDRG4 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	58,513,628 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,715,119 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; pons; ; lateral nuclear group of thalamus; ; right frontal lobe; ; prefrontal cortex; ; apex of heart; ; nucleus accumbens; ; cerebellar vermis; ; caudate nucleus; ; dorsolateral prefrontal cortex;
	Top expressed in
	olfactory tubercle; ; medial dorsal nucleus; ; medial geniculate nucleus; ; pontine nuclei; ; dorsal tegmental nucleus; ; habenula; ; medial vestibular nucleus; ; lateral geniculate nucleus; ; nucleus accumbens; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	cytosol; basolateral plasma membrane; cell projection membrane; cytoplasm; mitochondrion; endoplasmic reticulum membrane;
Biological process	visual learning; negative regulation of platelet-derived growth factor receptor signaling pathway; cell migration involved in heart development; cell differentiation; negative regulation of smooth muscle cell proliferation; regulation of endocytic recycling; negative regulation of smooth muscle cell migration; cardiac muscle cell proliferation; embryonic heart tube development; heart looping; cell growth; vesicle docking; positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; brain development; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	65009
	234593
	ENSG00000103034
	ENSMUSG00000036564
	Q9ULP0
	Q8BTG7
NM_001130487; NM_001242833; NM_001242834; NM_001242835; NM_001242836;
	NM_020465; NM_022910; NM_001363869
	NM_001195006; NM_145602
NP_001123959; NP_001229762; NP_001229763; NP_001229764; NP_001229765;
	NP_065198; NP_075061; NP_001350798; NP_001365261; NP_001365262; NP_001365263; NP_001365264; NP_001365265; NP_001365266; NP_001365267; NP_001365268; NP_001365269; NP_001365270; NP_001365271; NP_001365272; NP_001365273; NP_001365274; NP_001365275; NP_001365276
NP_001181935; NP_663577; NP_001359350; NP_001359352; NP_001359354;
	NP_001359355; NP_001359356; NP_001359357; NP_001359358; NP_001359359; NP_001359360; NP_001359361; NP_001359362; NP_001359363; NP_001359364
	Wikidata
View/Edit Human	View/Edit Mouse

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.^[5]^[6]^[7]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103034 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036564 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
^ Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". J Cell Biochem. 98 (1): 185–93. doi:10.1002/jcb.20763. PMID 16408304. S2CID 10192022.
^ ^a ^b "Entrez Gene: NDRG4 NDRG family member 4".