Protein-coding gene in the species Homo sapiens
Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene .
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Function
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].
References
Further reading
Mund T, Pelham HR (2009). "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins" . EMBO Rep . 10 (5): 501– 7. doi :10.1038/embor.2009.30 . PMC 2680872 PMID 19343052 . Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS (2009). "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons" . Proc. Natl. Acad. Sci. U.S.A . 106 (36): 15489– 94. Bibcode :2009PNAS..10615489H . doi :10.1073/pnas.0904880106 PMC 2741278 PMID 19706893 . Mund T, Pelham HR (2010). "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2" . Proc. Natl. Acad. Sci. U.S.A . 107 (25): 11429– 34. Bibcode :2010PNAS..10711429M . doi :10.1073/pnas.0911714107 PMC 2895104 PMID 20534535 . Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS (2011). "Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes" . J. Biol. Chem . 286 (10): 8555– 64. doi :10.1074/jbc.M110.203448 PMC 3048738 PMID 21187286 . Wang Y, Tong X, Ye X (2012). "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation" . J. Immunol . 189 (11): 5304– 13. doi :10.4049/jimmunol.1201445 PMID 23087404 . Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS (2014). "Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels" . PLOS ONE . 9 (1): e87119. Bibcode :2014PLoSO...987119H . doi :10.1371/journal.pone.0087119 PMC 3901732 PMID 24475238 . {{cite journal }}: CS1 maint: article number as page number (link )Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS (2015). "Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response" . J. Biol. Chem . 290 (11): 7141– 50. doi :10.1074/jbc.M114.613687 PMC 4358134 PMID 25631046 . Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y (2015). "Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells". Biochem. Biophys. Res. Commun . 465 (4): 851– 6. doi :10.1016/j.bbrc.2015.08.099 . PMID 26319551 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
