Swiss biomedical engineer
Matthias Lutolf (born in 1973, also known as Matthias Lütolf) is a bio-engineer and a professor at EPFL (École Polytechnique Fédérale de Lausanne) where he leads the Laboratory of Stem Cell Bioengineering.[ 1] [ 2] [ 3] [ 4] In 2021, he became the scientific director for Roche 's Institute for Translation Bioengineering in Basel .[ 5]
Career
Lutolf studied materials engineering at ETH Zurich where he graduated in 1998. In 2002, he received his PhD in biomedical engineering from ETH Zurich for his studies on cell-responsive hydrogels for tissue engineering and cell culture, in the group of Jeffrey Hubbell .[ 6] [ 7] He completed postdoctoral studies in the laboratory of Helen Blau at Stanford University , where he worked on novel cell culture approaches for blood and muscle stem cells, so called synthetic niches .[ 8] [ 9] In 2007, he founded his own laboratory at EPFL , where he was promoted to associate professor in 2014 and full professor in 2018.[ 1] From 2014 to 2018, he was director of EPFL 's Institute of Bioengineering.[ 10] In June 2021, Lutolf became scientific director of the newly established Roche Institute for Translational Bioengineering in Basel , Switzerland .[ 5]
Lutolf's laboratory develops in vitro organoids mimicking healthy and diseased tissues and organs.[ 2] [ 11] [ 12] [ 13] [ 14] [ 15] [ 16] [ 17]
In 2007, Lutolf received the European Young Investigator (EURYI ) Award by the European Science Foundation .[ 18] Since 2018, he is elected as member of the European Molecular Biology Organization (EMBO).[ 19] He serves as associate editor of The Company of Biologists ' journal Development .[ 20]
Publications
External links
References
^ a b "13 new professors appointed at ETH Zurich and EPFL | ETH-Board" . www.ethrat.ch . Retrieved 2021-08-20 .
^ a b "Laboratory of Stem Cell Bioengineering - EPFL" . www.epfl.ch . Retrieved 2021-08-20 .
^ "Institute of Chemical Sciences and Engineering – ISIC" . www.epfl.ch . Retrieved 2020-08-24 .
^ "Laboratory of Stem Cell Bioengineering - EPFL" . www.epfl.ch . Retrieved 2020-08-24 .
^ a b "The Roche Institute for Translational Bioengineering" . www.roche.com . Retrieved 2021-08-20 .
^ Lütolf, Matthias (2002). Cell-responsive synthetic hydrogels (Doctoral Thesis thesis). ETH Zurich.
^ Lutolf, Matthias P.; Weber, Franz E.; Schmoekel, Hugo G.; Schense, Jason C.; Kohler, Thomas; Müller, Ralph; Hubbell, Jeffrey A. (May 2003). "Repair of bone defects using synthetic mimetics of collagenous extracellular matrices" . Nature Biotechnology . 21 (5): 513– 518. doi :10.1038/nbt818 . ISSN 1087-0156 . PMID 12704396 . S2CID 7144594 .
^ Lutolf, Matthias P.; Gilbert, Penney M.; Blau, Helen M. (November 2009). "Designing materials to direct stem-cell fate" . Nature . 462 (7272): 433– 441. Bibcode :2009Natur.462..433L . doi :10.1038/nature08602 . ISSN 1476-4687 . PMC 2908011 . PMID 19940913 .
^ Gilbert, P. M.; Havenstrite, K. L.; Magnusson, K. E. G.; Sacco, A.; Leonardi, N. A.; Kraft, P.; Nguyen, N. K.; Thrun, S.; Lutolf, M. P.; Blau, H. M. (2010-08-27). "Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture" . Science . 329 (5995): 1078– 1081. Bibcode :2010Sci...329.1078G . doi :10.1126/science.1191035 . ISSN 0036-8075 . PMC 2929271 . PMID 20647425 .
^ Bhagwat, V. M.; Ramachandran, B. V. (1975-09-15). "Malathion A and B esterases of mouse liver-I". Biochemical Pharmacology . 24 (18): 1713– 1717. doi :10.1016/0006-2952(75)90011-8 . ISSN 0006-2952 . PMID 14 .
^ Gjorevski, Nikolce; Sachs, Norman; Manfrin, Andrea; Giger, Sonja; Bragina, Maiia E.; Ordóñez-Morán, Paloma; Clevers, Hans; Lutolf, Matthias P. (November 2016). "Designer matrices for intestinal stem cell and organoid culture" . Nature . 539 (7630): 560– 564. doi :10.1038/nature20168 . ISSN 1476-4687 . PMID 27851739 . S2CID 4470849 .
^ Caiazzo, Massimiliano; Okawa, Yuya; Ranga, Adrian; Piersigilli, Alessandra; Tabata, Yoji; Lutolf, Matthias P. (March 2016). "Defined three-dimensional microenvironments boost induction of pluripotency" . Nature Materials . 15 (3): 344– 352. Bibcode :2016NatMa..15..344C . doi :10.1038/nmat4536 . ISSN 1476-4660 . PMID 26752655 .
^ Gobaa, Samy; Hoehnel, Sylke; Roccio, Marta; Negro, Andrea; Kobel, Stefan; Lutolf, Matthias P. (November 2011). "Artificial niche microarrays for probing single stem cell fate in high throughput" . Nature Methods . 8 (11): 949– 955. doi :10.1038/nmeth.1732 . ISSN 1548-7105 . PMID 21983923 . S2CID 310516 .
^ Ranga, A.; Gobaa, S.; Okawa, Y.; Mosiewicz, K.; Negro, A.; Lutolf, M. P. (2014-07-14). "3D niche microarrays for systems-level analyses of cell fate" . Nature Communications . 5 (1): 4324. Bibcode :2014NatCo...5.4324R . doi :10.1038/ncomms5324 . ISSN 2041-1723 . PMC 4104440 . PMID 25027775 .
^ Brandenberg, Nathalie; Hoehnel, Sylke; Kuttler, Fabien; Homicsko, Krisztian; Ceroni, Camilla; Ringel, Till; Gjorevski, Nikolce; Schwank, Gerald; Coukos, George; Turcatti, Gerardo; Lutolf, Matthias P. (September 2020). "High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays" . Nature Biomedical Engineering . 4 (9): 863– 874. doi :10.1038/s41551-020-0565-2 . ISSN 2157-846X . PMID 32514094 . S2CID 219543643 .
^ Brassard, Jonathan A.; Nikolaev, Mike; Hübscher, Tania; Hofer, Moritz; Lutolf, Matthias P. (January 2021). "Recapitulating macro-scale tissue self-organization through organoid bioprinting" . Nature Materials . 20 (1): 22– 29. Bibcode :2021NatMa..20...22B . doi :10.1038/s41563-020-00803-5 . ISSN 1476-4660 . PMID 32958879 . S2CID 221825383 .
^ Nikolaev, Mikhail; Mitrofanova, Olga; Broguiere, Nicolas; Geraldo, Sara; Dutta, Devanjali; Tabata, Yoji; Elci, Bilge; Brandenberg, Nathalie; Kolotuev, Irina; Gjorevski, Nikolce; Clevers, Hans (September 2020). "Homeostatic mini-intestines through scaffold-guided organoid morphogenesis" . Nature . 585 (7826): 574– 578. Bibcode :2020Natur.585..574N . doi :10.1038/s41586-020-2724-8 . ISSN 1476-4687 . PMID 32939089 . S2CID 221769498 .
^ "2007 : European Science Foundation" . archives.esf.org . Retrieved 2021-08-20 .
^ "Find people in the EMBO Communities" . people.embo.org . Retrieved 2021-08-20 .
^ "Editors and Board | Development | The Company of Biologists | Development | The Company of Biologists" . journals.biologists.com . Retrieved 2021-08-20 .