Mast cell stabilizers are medications used to prevent or treat certain allergic disorders. They block degranulation or mast cell, stabilizing it and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.[1]
^Castells M, Butterfield J (April 2019). "Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management". J Allergy Clin Immunol Pract. 7 (4): 1097–1106. doi:10.1016/j.jaip.2019.02.002. PMID30961835.
^ abcdChadwick SJ (15 May 2009). "Principles of Allergy Management". Managing the Allergic Patient. pp. 19–72. doi:10.1016/B978-141603677-7.50006-6. ISBN978-1-4160-3677-7. Sodium cromoglycate (cromolyn sodium) has now been available in an intranasal format OTC for almost 10 years[...] Nedocromil is much more potent [...] Other ophthalmic mast cell stabilizers include cromolyn sodium, ketotifen, and pemirolast, and topical antihistamines such as olopatadine also demonstrate mast-cell stabilizing effects. Cromolyn sodium is also used as an oral preparation for the treatment of mastocytosis and has been used off-label in the management of food allergy
^Wang Y, Liu Z, Zhou W, Wang J, Li R, Peng C, et al. (February 2024). "Mast cell stabilizer, an anti-allergic drug, reduces ventricular arrhythmia risk via modulation of neuroimmune interaction". Basic Res Cardiol. 119 (1): 75–91. doi:10.1007/s00395-023-01024-y. PMID38172251.
^ abFeuille EJ, Phipatanakul W, Permaul P (2022). "Conventional medications for the treatment of allergic rhinitis and conjunctivitis". Allergic and Immunologic Diseases. pp. 1077–1109. doi:10.1016/B978-0-323-95061-9.00038-2. ISBN978-0-323-95061-9. Evidence is insufficient to compare the efficacy of available ocular mast cell stabilizers (cromolyn, lodoxamide, nedocromil)
^Chu R, Bajaj P (2025). Asthma Medication in Children. PMID28722853.
