Protein coding gene in Homo sapiens
Myotrophin is a protein that in humans is encoded by the MTPN gene .[ 5] [ 6]
Interactions
MTPN has been shown to interact with RELA [ 7] REL .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000105887 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029840 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet . 93 (1– 2): 151– 2. doi :10.1159/000056974 . PMID 11474205 . S2CID 30646120 . ^ "Entrez Gene: MTPN myotrophin" .^ a b Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers" . J. Biol. Chem . 277 (26). United States: 23888– 97. doi :10.1074/jbc.M202937200 ISSN 0021-9258 . PMID 11971907 .
Further reading
Taoka M, Yamakuni T, Song SY, et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif" . Eur. J. Biochem . 207 (2): 615– 20. doi :10.1111/j.1432-1033.1992.tb17088.x PMID 1633812 . Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart" . Circ. Res . 73 (1): 98– 108. doi :10.1161/01.res.73.1.98 PMID 8508536 . Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro" . J. Biol. Chem . 271 (5): 2812– 6. doi :10.1074/jbc.271.5.2812 PMID 8576259 . Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy". J. Mol. Cell. Cardiol . 31 (4): 705– 19. doi :10.1006/jmcc.1998.0903 . PMID 10329199 . Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788– 95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422– 35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287– 92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Knuefermann P, Chen P, Misra A, et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers" . J. Biol. Chem . 277 (26): 23888– 97. doi :10.1074/jbc.M202937200 PMID 11971907 . Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy". Biochim. Biophys. Acta . 1589 (3): 247– 60. doi :10.1016/S0167-4889(02)00178-7 . PMID 12031792 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology" . Science . 300 (5620): 767– 72. Bibcode :2003Sci...300..767S . doi :10.1126/science.1083423 . PMC 2882961 PMID 12690205 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157– 64. Bibcode :2003Natur.424..157H . doi :10.1038/nature01782 PMID 12853948 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline" . Genome Res . 14 (10B): 2136– 44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Xiong Z, Liu E, Yan Y, et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions" . J. Immunol . 177 (7): 4907– 16. doi :10.4049/jimmunol.177.7.4907 . PMC 3902139 PMID 16982933 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
PDB gallery
1myo : SOLUTION STRUCTURE OF MYOTROPHIN, NMR, 44 STRUCTURES
2myo : SOLUTION STRUCTURE OF MYOTROPHIN, NMR, MINIMIZED AVERAGE STRUCTURE
