Protein-coding gene in the species Homo sapiens
U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene .[ 4] [ 5] [ 6]
Function
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2 ). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing .[ 6]
References
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037296 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T (Jan 2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489– 501. doi :10.1017/S1355838202021726 . PMC 1370355 PMID 12515382 . ^ Takahashi S, Suzuki S, Inaguma S, Cho YM, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T (Apr 2002). "Down-regulation of Lsm1 is involved in human prostate cancer progression" . Br J Cancer . 86 (6): 940– 6. doi :10.1038/sj.bjc.6600163 . PMC 2364150 PMID 11953827 . ^ a b "Entrez Gene: LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .
Further reading
Shimizu Y, Sugiyama H, Fujii Y, et al. (1997). "Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells" . Am. J. Hematol . 54 (1): 1– 11. doi :10.1002/(SICI)1096-8652(199701)54:1<1::AID-AJH1>3.0.CO;2-1 PMID 8980254 . Schweinfest CW, Graber MW, Chapman JM, et al. (1997). "CaSm: an Sm-like protein that contributes to the transformed state in cancer cells". Cancer Res . 57 (14): 2961– 5. PMID 9230209 . Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin" . EMBO J . 18 (12): 3451– 62. doi :10.1093/emboj/18.12.3451 . PMC 1171424 PMID 10369684 . Achsel T, Brahms H, Kastner B, et al. (1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . EMBO J . 18 (20): 5789– 802. doi :10.1093/emboj/18.20.5789 . PMC 1171645 PMID 10523320 . Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)" . J. Biol. Chem . 275 (34): 26370– 5. doi :10.1074/jbc.M003299200 PMID 10851237 . Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera" . Arthritis Rheum . 46 (3): 726– 34. doi :10.1002/art.10220 PMID 11920408 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153– 67. doi :10.1016/S0888-7543(03)00235-0 . PMID 14667819 . Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation" . Genome Res . 14 (7): 1315– 23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Wichroski MJ, Robb GB, Rana TM (2006). "Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies" . PLOS Pathog . 2 (5): e41. doi :10.1371/journal.ppat.0020041 PMC 1458959 PMID 16699599 . Chu CY, Rana TM (2006). "Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54" . PLOS Biol . 4 (7): e210. doi :10.1371/journal.pbio.0040210 PMC 1475773 PMID 16756390 . Streicher KL, Yang ZQ, Draghici S, Ethier SP (2007). "Transforming function of the LSM1 oncogene in human breast cancers with the 8p11−12 amplicon" . Oncogene . 26 (14): 2104– 14. doi :10.1038/sj.onc.1210002 . PMC 2435249 PMID 17001308 .
