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IWS1

IWS1

Identifiers

IWS1, SUPT6H interacting protein, interacts with SUPT6H, CTD assembly factor 1

External IDs

MGI: 1920723; HomoloGene: 134421; GeneCards: IWS1; OMA:IWS1 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q14.3	Start	127,436,207 bp^[1]
Band	2q14.3	End	127,526,886 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 B1	Start	32,200,794 bp^[2]
Band	18\|18 B1	End	32,237,381 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tibialis anterior muscle

mucosa of ileum

Achilles tendon

tendon of biceps brachii

gastrocnemius muscle

gonad

right auricle of heart

sural nerve

left ventricle

apex of heart

Top expressed in

tail of embryo

hand

otolith organ

utricle

genital tubercle

superior cervical ganglion

zygote

trigeminal ganglion

spermatocyte

spermatid

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	nucleus nucleoplasm
Biological process	regulation of transcription, DNA-templated mRNA transport RNA splicing regulation of histone H4 acetylation regulation of mRNA processing mRNA processing regulation of mRNA export from nucleus regulation of histone H3-K36 trimethylation transcription, DNA-templated transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter regulation of DNA-templated transcription, elongation
Sources:Amigo / QuickGO

Species

Human

Mouse


55677


73473


ENSG00000163166


ENSMUSG00000024384


Q96ST2


Q8C1D8

RefSeq (mRNA)


NM_017969


NM_173441

RefSeq (protein)


NP_060439


NP_775617

Location (UCSC)

Chr 2: 127.44 – 127.53 Mb

Chr 18: 32.2 – 32.24 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.^[5]

IWS1 is a transcription elongation factor. It was first identified during a search for RNA polymerase II-associated elongation factors in yeast; it directly interacts with RNA polymerase II (RNAPII) and is phosphorylated at casein kinase II (CKII) sites.^[6]

The human homolog, which physically interacts with protein arginine methyltransferase 5 (PRMT5), is essential for cell survival.^[7] It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163166 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024384 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IWS1 IWS1 homolog (S. cerevisiae)".
^ Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF (Oct 2002). "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach". Molecular and Cellular Biology. 22 (20): 6979–92. doi:10.1128/MCB.22.20.6979-6992.2002. PMC 139818. PMID 12242279.
^ Liu Z, Zhou Z, Chen G, Bao S (Feb 2007). "A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation". Biochemical and Biophysical Research Communications. 353 (1): 47–53. doi:10.1016/j.bbrc.2006.11.133. PMID 17184735.
^ Yoh SM, Lucas JS, Jones KA (Dec 2008). "The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation". Genes & Development. 22 (24): 3422–34. doi:10.1101/gad.1720008. PMC 2607075. PMID 19141475.

Further reading

Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Ling Y, Smith AJ, Morgan GT (2006). "A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting by human TFIIS". Nucleic Acids Research. 34 (8): 2219–29. doi:10.1093/nar/gkl239. PMC 1450333. PMID 16648364.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Liu Z, Zhou Z, Chen G, Bao S (Feb 2007). "A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation". Biochemical and Biophysical Research Communications. 353 (1): 47–53. doi:10.1016/j.bbrc.2006.11.133. PMID 17184735.
Yoh SM, Cho H, Pickle L, Evans RM, Jones KA (Jan 2007). "The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export". Genes & Development. 21 (2): 160–74. doi:10.1101/gad.1503107. PMC 1770899. PMID 17234882.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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