Protein-coding gene in the species Homo sapiens
Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene .[ 5] [ 6] [ 7]
Function
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[ 7] [ 8]
Interactions
INSM1 has been shown to interact with SORBS1 .[ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000173404 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068154 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lan MS, Li Q, Lu J, Modi WS, Notkins AL (May 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1" . The Journal of Biological Chemistry . 269 (19): 14170– 4. doi :10.1016/S0021-9258(17)36770-4 PMID 8188699 . ^ Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (July 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases" . The Biochemical Journal . 397 (1): 169– 77. doi :10.1042/BJ20051669 . PMC 1479746 PMID 16569215 . ^ a b "Entrez Gene: INSM1 insulinoma-associated 1" .^ Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF (August 2018). "Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections" . Modern Pathology . 32 (1): 100– 109. doi :10.1038/s41379-018-0122-7 PMID 30154579 . S2CID 52110673 . ^ Xie J, Cai T, Zhang H, Lan MS, Notkins AL (July 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein" . Genomics . 80 (1): 54– 61. doi :10.1006/geno.2002.6800 . PMC 1237014 PMID 12079283 .
Further reading
Goto Y, De Silva MG, Toscani A, Prabhakar BS, Notkins AL, Lan MS (July 1992). "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs" . The Journal of Biological Chemistry . 267 (21): 15252– 7. doi :10.1016/S0021-9258(18)42173-4 PMID 1634555 . Li Q, Notkins AL, Lan MS (July 1997). "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1" . Biochemical and Biophysical Research Communications . 236 (3): 776– 81. doi :10.1006/bbrc.1997.7054 . PMID 9245732 . Breslin MB, Zhu M, Notkins AL, Lan MS (February 2002). "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence" . Nucleic Acids Research . 30 (4): 1038– 45. doi :10.1093/nar/30.4.1038 . PMC 100352 PMID 11842116 . Zhu M, Breslin MB, Lan MS (March 2002). "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells". Pancreas . 24 (2): 139– 45. doi :10.1097/00006676-200203000-00004 . PMID 11854618 . S2CID 23037260 . Xie J, Cai T, Zhang H, Lan MS, Notkins AL (July 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein" . Genomics . 80 (1): 54– 61. doi :10.1006/geno.2002.6800 . PMC 1237014 PMID 12079283 . Breslin MB, Zhu M, Lan MS (October 2003). "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system" . The Journal of Biological Chemistry . 278 (40): 38991– 7. doi :10.1074/jbc.M306795200 PMC 1236987 PMID 12890672 . Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS (February 2009). "Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest" . The Journal of Biological Chemistry . 284 (9): 5574– 81. doi :10.1074/jbc.M808843200 PMC 2645817 PMID 19124461 .
