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GRIPAP1

GRIPAP1

Identifiers

GRIPAP1, GRASP-1, GRIP1 associated protein 1

External IDs

OMIM: 300408; MGI: 1859616; HomoloGene: 41348; GeneCards: GRIPAP1; OMA:GRIPAP1 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xp11.23	Start	48,973,720 bp^[1]
Band	Xp11.23	End	49,002,264 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	X A1.1\|X 3.51 cM	Start	7,656,004 bp^[2]
Band	X A1.1\|X 3.51 cM	End	7,686,806 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

right frontal lobe

sural nerve

anterior pituitary

cingulate gyrus

anterior cingulate cortex

Brodmann area 9

prefrontal cortex

granulocyte

hypothalamus

Top expressed in

granulocyte

neural layer of retina

superior frontal gyrus

primary visual cortex

dentate gyrus of hippocampal formation granule cell

cerebellar cortex

yolk sac

nucleus of stria terminalis

ventricular zone

central gray substance of midbrain

More reference expression data

n/a

Gene ontology
Molecular function	protein binding molecular function
Cellular component	endosome blood microparticle nucleoplasm cytosol intracellular membrane-bounded organelle postsynaptic recycling endosome membrane cell junction axon dendrite early endosome membrane cell projection synapse recycling endosome membrane glutamatergic synapse extrinsic component of postsynaptic early endosome membrane
Biological process	neurotransmitter receptor transport, endosome to postsynaptic membrane regulation of modification of synaptic structure transport protein transport biological process regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane regulation of recycling endosome localization within postsynapse
Sources:Amigo / QuickGO

Species

Human

Mouse


56850


54645


ENSG00000068400


ENSMUSG00000031153


Q4V328


Q8VD04

RefSeq (mRNA)


NM_020137 NM_207672

NM_001290455 NM_207670 NM_001359289 NM_001359290 NM_001359291
NM_001359293

RefSeq (protein)


NP_064522

NP_001277384 NP_997553 NP_001346218 NP_001346219 NP_001346220
NP_001346222

Location (UCSC)

Chr X: 48.97 – 49 Mb

Chr X: 7.66 – 7.69 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.^[5]^[6]

Function

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM]^[6]

Interactions

GRIPAP1 has been shown to interact with GRIP1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068400 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031153 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.
^ ^a ^b "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

Further reading

Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP (2002). "Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex". J. Biol. Chem. 277 (4): 2396–405. doi:10.1074/jbc.M106312200. PMID 11704662.
Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. hdl:2262/89271. PMID 11891216.
Ye B, Sugo N, Hurn PD, Huganir RL (2002). "Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody". Neuroscience. 114 (1): 217–27. doi:10.1016/S0306-4522(02)00142-2. PMID 12207967. S2CID 39432674.
Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes Cells. 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Stinton LM, Selak S, Fritzler MJ (2005). "Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes". Clin. Immunol. 116 (2): 108–17. doi:10.1016/j.clim.2005.03.021. PMID 15897011.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

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