Protein-coding gene in the species Homo sapiens
Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene .[ 5] [ 6] [ 7]
Sulfonation , an important step in the metabolism of many drugs, xenobiotics , hormones, and neurotransmitters, is catalyzed by sulfotransferases . The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000128242 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049721 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence" . Genome Res . 8 (11): 1097– 108. doi :10.1101/gr.8.11.1097 PMID 9847074 . ^ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase" . J Biol Chem . 272 (8): 4864– 8. doi :10.1074/jbc.272.8.4864 PMID 9030544 . ^ a b "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1" .
Further reading
Siegrist HP, Jutzi H, Steck AJ, et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta . 489 (1): 58– 63. doi :10.1016/0005-2760(77)90231-4 . PMID 911873 . Stein C, Gieselmann V, Kreysing J, et al. (1989). "Cloning and expression of human arylsulfatase A" . J. Biol. Chem . 264 (2): 1252– 9. doi :10.1016/S0021-9258(19)85079-2 PMID 2562955 . Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun . 52 (3): 951– 8. doi :10.1016/0006-291X(73)91029-2 . PMID 4710574 . Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain" . J. Biol. Chem . 246 (15): 4694– 702. doi :10.1016/S0021-9258(18)61991-X PMID 5562350 . Costantino-Ceccarini E, Waehneldt TV, Ginalski H, et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res . 7 (1): 1– 12. doi :10.1007/BF00965064 . PMID 6280086 . S2CID 32069166 . Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem . 38 (1): 233– 41. doi :10.1111/j.1471-4159.1982.tb10875.x . PMID 6955451 . S2CID 23693243 . Honke K, Yamane M, Ishii A, et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells" . J. Biochem . 119 (3): 421– 7. doi :10.1093/oxfordjournals.jbchem.a021258 PMID 8830034 . Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene" . Eur. J. Biochem . 267 (9): 2672– 9. doi :10.1046/j.1432-1327.2000.01281.x PMID 10785389 . Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase" . Biochem. J . 368 (Pt 1): 317– 24. doi :10.1042/BJ20020946 . PMC 1222978 PMID 12175333 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 PMC 545604 PMID 15461802 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
