FANCD2OS

FANCD2OS
Identifiers
Aliases	FANCD2OS, C3orf24, FANCD2 opposite strand
External IDs	MGI: 1918229; HomoloGene: 45456; GeneCards: FANCD2OS; OMA:FANCD2OS - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,081,317 bp[1] End 10,108,255 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E3 Start 113,573,722 bp[2] End 113,577,676 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis pancreatic ductal cell sperm testicle gonad muscle tissue granulocyte minor salivary glands gastric mucosa Top expressed in seminiferous tubule spermatid proximal tubule morula embryo right kidney human kidney spermatocyte blastocyst blastocyst More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 115795 70979 Ensembl ENSG00000163705 ENSMUSG00000033963 UniProt Q96PS1 Q9D4K4 RefSeq (mRNA) NM_173472 NM_001164839 NM_027633 RefSeq (protein) NP_001158311 NP_775743 NP_081909 Location (UCSC) Chr 3: 10.08 – 10.11 Mb Chr 6: 113.57 – 113.58 Mb PubMed search [3] [4]
Wikidata
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Fanconi Anemia Opposite Strand Transcript protein is a predicted protein that in humans is encoded by the FANCD2OS gene.^[5] The name is derived from mRNA transcribed from the strand complementary to the FANCD2 gene.

The gene is encoded on Chromosome 3 (human) at p25.3 on the minus strand from 10081320-10108339nt. The primary transcript is 1105nt which codes for a protein of 177 amino acid in length.^[6] The gene on the strand complementary to FANCD2 located 5' from CYCSP11 and 3’ from BRK1 and VHL genes.^[5]

There are six alternatively spliced transcripts with differences in the 5' and 3' ends as well changes in exon usage.^[7] The most common isoform is 1105 bp.^[8]

The promoter region predicted by the Genomatix El Dorado algorithm spans from 10108742-10108009 bp. Promoters are associated with a wide variety of tissues including B-lymphocytes, germ cells, muscle, neurons & prostate.

Secondary structure of the 5’ UTR sequence conserved between humans and gibbon contain sequence recognized by to RBMX, Ras & Rab proteins. The sequence for the secondary structure of the 3’ UTR are recognized by EIF4B and RBMX.

FANCD2OS is moderately expressed in the human brain, placenta and testes.^[9]

The protein from the longest transcript is 177AA in length with a mass of 20188.59kD. The protein consists of a domain of unknown function from the DUF4563 superfamily.^[10]

Orthologs of FANCD2OS exist throughout mammals, reptiles, birds and in the cartilaginous fish Australian ghostshark.^[11] The protein sequence undergoes mutation at a rate similar to the blood protein fibrinogen.

FANCD2OS has no known paralogs in Homo sapiens.

^{[6] [5] [11] [7] [10] [9]}