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MPHOSPH10

MPHOSPH10

Identifikatori

Vanjski ID-jevi

OMIM: 605503 MGI: 1915223 HomoloGene: 134741 GeneCards: MPHOSPH10

Lokacija gena (čovjek)

Hrom.	Hromosom 2 (čovjek)^[1]

Bend	2p13.3	Početak	71,130,310 bp^[1]
Bend	2p13.3	Kraj	71,150,101 bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom 7 (miš)^[2]

Bend	7\|7 C	Početak	64,026,275 bp^[2]
Bend	7\|7 C	Kraj	64,042,016 bp^[2]

Obrazac RNK ekspresije

Više referentnih podataka o ekspresiji

Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK
Ćelijska komponenta	• sno(s)RNA-containing ribonucleoprotein complex • small-subunit processome • Mpp10 complex • Jedarce • jedro • hromosom • nukleoplazma
Biološki proces	• RNA splicing, via transesterification reactions • negative regulation of phosphatase activity • GO:0033168, GO:0036404, GO:1902360 RNA processing • ribosome biogenesis • Prerada RNK • rRNA processing • maturation of SSU-rRNA
Izvori:Amigo / QuickGO

Vrste

Čovjek

Miš


10199


67973


ENSG00000124383


ENSMUSG00000030521


O00566


Q810V0

RefSeq (mRNK)


NM_005791


NM_026483

RefSeq (bjelančevina)


NP_005782


NP_080759

Lokacija (UCSC)

Chr 2: 71.13 – 71.15 Mb

Chr 7: 64.03 – 64.04 Mb

PubMed pretraga

^[3]

^[4]

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

U3 mali jedarčani ribonukleoproteinski protein MPP10 jest protein koji je kod ljudi kodiran genom MPHOSPH10 sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 681 aminokiselina, a molkekulska iežina 78.864 Da.^[8]

D: Asparaginska kiselina

E: Glutaminska kiselina

Y: Tirozin

10		20		30		40		50
MAPQVWRRRT		LERCLTEVGK		ATGRPECFLT		IQEGLASKFT		SLTKVLYDFN
KILENGRIHG		SPLQKLVIEN		FDDEQIWQQL		ELQNEPILQY		FQNAVSETIN
DEDISLLPES		EEQEREEDGS		EIEADDKEDL		EDLEEEEVSD		MGNDDPEMGE
RAENSSKSDL		RKSPVFSDED		SDLDFDISKL		EQQSKVQNKG		QGKPREKSIV
DDKFFKLSEM		EAYLENIEKE		EERKDDNDEE		EEDIDFFEDI		DSDEDEGGLF
GSKKLKSGKS		SRNLKYKDFF		DPVESDEDIT		NVHDDELDSN		KEDDEIAEEE
AEELSISETD		EDDDLQENED		NKQHKESLKR		VTFALPDDAE		TEDTGVLNVK
KNSDEVKSSF		EKRQEKMNEK		IASLEKELLE		KKPWQLQGEV		TAQKRPENSL
LEETLHFDHA		VRMAPVITEE		TTLQLEDIIK		QRIRDQAWDD		VVRKEKPKED
AYEYKKRLTL		DHEKSKLSLA		EIYEQEYIKL		NQQKTAEEEN		PEHVEIQKMM
DSLFLKLDAL		SNFHFIPKPP		VPEIKVVSNL		PAITMEEVAP		VSVSDAALLA
PEEIKEKNKA		GDIKTAAEKT		ATDKKRERRK		KKYQKRMKIK		EKEKRRKLLE
KSSVDQAGKY		SKTVASEKLK		QLTKTGKASF		IKDEGKDKAL		KSSQAFFSKL
QDQVKMQIND		AKKTEKKKKK		RQDISVHKLK		L

Funkcija

Ovaj gen kodira protein koji se fosforilira tokom mitoze. Protein se nalazi na nukleolusu tokom interfaze i na hromosomima tokom M-faze. Smatra se da je protein dio U3 malog jedarcetovog proteinskog kompleksa, koji je uključen u preradu rRNK.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124383 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030521 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
^ Westendorf JM, Konstantinov KN, Wormsley S, Shu MD, Matsumoto-Taniura N, Pirollet F, Klier FG, Gerace L, Baserga SJ (Mar 1998). "M Phase Phosphoprotein 10 Is a Human U3 Small Nucleolar Ribonucleoprotein Component". Mol Biol Cell. 9 (2): 437–49. doi:10.1091/mbc.9.2.437. PMC 25272. PMID 9450966.
^ ^a ^b "Entrez Gene: MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)".
^ "UniProt, O00566" (jezik: engleski). Pristupljeno 13. 11. 2021.

Dopunska literatura

Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60–80S ribonucleoprotein complexes". Nucleic Acids Res. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC 152815. PMID 12655004.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi

MPHOSPH10 lokacija ljudskog genoma UCSC Genome Browser.

MPHOSPH10 detalji ljudskog genoma u UCSC Genome Browser.

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Prefix: a b c d e f g h i j k l m n o p q r s t u v w x y z 0 1 2 3 4 5 6 7 8 9

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